Pcgf6 Antibodies

AND Pcgf6 ELISA kits, Pcgf6 Proteins

Many biological assays use antibodies to detect Pcgf6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pcgf6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pcgf6 antibodies...

We validate the specificity of these antibodies to Pcgf6 by testing them on tissues known to express Pcgf6 positively and negatively. Browse below to find the Pcgf6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Pcgf6 Infographic by Boster Bio

All Pcgf6 Products

Product

Figures

Specificity

Applications

Price

Anti-PCGF6 Antibody (C-term)

Human

IF, WB

$298
Cat # A07034-1
80 µl

Anti-PCGF6 Antibody (Center)

Human, Rat

$298
Cat # A07034
80 µl

PCGF6 (NM_001011663) Human Over-expression Lysate

Human

$628
Cat # LS084108
100 µg

Pcgf6 Overview

Facts about Polycomb group RING finger protein 6.

Polycomb group RING finger protein 6 (Pcgf6)

Transcriptional repressor. May modulate the amount of histone H3K4Me3 by activating KDM5D histone demethylase.

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility.

Gene Information

Mouse
Gene Name:	Pcgf6
Uniprot:	Q99NA9
Entrez:	71041

Family

Belongs to:

No superfamily

Alternative Names

MBLRMel18 and Bmi1-like RING finger protein; MGC15678; MGC17541; polycomb group ring finger 6; RING finger protein 134polycomb group RING finger protein 6; RNF134Mel18 and Bmi1-like RING finger

Molecular Weight

Mass (kDA):
39.82 kDA

Genomic Context


Mouse

Location:	19\|19 C3
Sequence:	19;

Tissue Specificity

Expressed in ovary, testis, stomach, liver, thymus and kidney (at protein level).

Diseases

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Progeria
Disease Of Adrenal Medulla
Malnutrition
Melanoma
Malignant Neoplasm Of Breast
Neoplasms, Experimental
Premature Aging Syndrome
Behavioral Tic
Immunologic Deficiency Syndromes

Animal Mammary Neoplasms
Severe Combined Immunodeficiency
Lymphopenia
Mucosa-associated Lymphoid Tissue Lymphoma
Headache
Lymphoma
Eosinophilia

Pathways

Cell Proliferation
Cell Cycle
Methylation
Interphase
Chromatin Remodeling
Cell Development
Demethylation
Senescence
Cell Migration
Gene Silencing
Cellular Senescence
Aging
Fibroblast Proliferation

Regulation Of Gene Expression
Cell Cycle Arrest
Cell Division
Paraxial Mesoderm Development
Reverse Transcription
Cell Differentiation
Histone Lysine Methylation

PTMs

Methylation
Demethylation

Phosphorylation
Dephosphorylation

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pcgf6

References

PMID: 12167161 by Akasaka T., et al. MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.