PHEX Antibodies

AND PHEX ELISA kits, PHEX Proteins

Many biological assays use antibodies to detect PHEX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHEX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHEX antibodies...

We validate the specificity of these antibodies to PHEX by testing them on tissues known to express PHEX positively and negatively. Browse below to find the PHEX antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHEX Infographic by Boster Bio

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Anti-PHEX Antibody Picoband®

1 Citations

Western blot analysis of PHEX using anti-PHEX antibody (A02078)

IHC analysis of PHEX using anti-PHEX antibody (A02078)

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A02078
100 μg/vial

PHEX Overview

Facts about Phosphate-regulating neutral endopeptidase PHEX.

PHEX 3D structure. Source: alphafold

Phosphate-regulating neutral endopeptidase PHEX (PHEX)

Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-based ASARM peptides, thus regulating their biological activity (PubMed:9593714, PubMed:15664000, PubMed:18162525, PubMed:18597632). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632).

Regulates osteogenic cell differentiation and bone mineralization through the cleavage of this MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18597632, PubMed:18162525).

Gene Information

Human
Gene Name:	PHEX
Uniprot:	P78562
Entrez:	5251

Family

Belongs to:

peptidase M13 family

Alternative Names

Phosphate-regulating neutral endopeptidase PHEX

Molecular Weight

Mass (kDA):
86.474 kDA

Genomic Context


Human

Location:	Xp22.11
Sequence:	X; NC_000023.11 (22032325..22251310)

Tissue Specificity

Specifically expressed in ovary (PubMed:9070861). Expressed at low levels in kidney (PubMed:9070861).

Subcellular Localizations

Cell membrane; Single-pass type II membrane protein.

Diseases

Hypophosphatemic rickets, X-linked dominant (XLHR)

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHEX

References

PMID: 9199930 by Francis F., et al. Genomic organization of the human PEX gene mutated in X-linked dominant hypophosphatemic rickets.

PMID: 9077527 by Beck L., et al. Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.