PHD finger protein 1 (PHF1)

Polycomb group (PcG) that specifically binds histone H3 trimethylated in'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs).

Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however uncertain whether recruitment of the PRC2 complex to H3K36me3 contributes to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 to H3K36me3 loci (PubMed:18285464 and PubMed:23273982).