1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (Plcd3)

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores.

Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 in the cleavage furrow.