POLD2 Antibodies

AND POLD2 ELISA kits, POLD2 Proteins

Many biological assays use antibodies to detect POLD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POLD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POLD2 antibodies...

We validate the specificity of these antibodies to POLD2 by testing them on tissues known to express POLD2 positively and negatively. Browse below to find the POLD2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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POLD2 Infographic by Boster Bio

All POLD2 Products

Product

Figures

Specificity

Applications

Price

Anti-DNA polymerase delta subunit 2 POLD2 Antibody

Human, Mouse, Rat

$405
Cat # A06147
100ul

DNA polymerase delta p50 (POLD2) (NM_006230) Human Recombinant Protein

$1249
Cat # PROTP49005
20 µg

POLD2 Overview

Facts about DNA polymerase delta subunit 2.

POLD2 3D structure. Source: alphafold

DNA polymerase delta subunit 2 (POLD2)

As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4.

They exhibit differences in catalytic activity. Most notably, Pol- delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433).

Gene Information

Human
Gene Name:	POLD2
Uniprot:	P49005
Entrez:	5425

Family

Belongs to:

DNA polymerase delta/II small subunit family

Alternative Names

delta 2, regulatory subunit (50kD); polymerase (DNA directed), delta 2, regulatory subunit 50kDa

Molecular Weight

Mass (kDA):
51.289 kDA

Genomic Context


Human

Location:	7p13
Sequence:	7; NC_000007.14 (44114680..44123668, complement)

Subcellular Localizations

Nucleus. Recruited to DNA damage sites within 2 hours following UV irradiation.

Diseases

Malignant Neoplasms
Fracture Of First Cervical Vertebra
Glioma
Glioblastoma
Columnar Cell Change Of The Breast
Acute Lymphocytic Leukemia
Brain Neoplasms
Carcinoma
Neoplasms, Glandular And Epithelial
Osteosarcoma
Ovarian Cysts
Neoplasms

Cystadenocarcinoma, Serous
Malignant Neoplasm Of Ovary
Epithelial Ovarian Cancer
Ovarian Neoplasm
Cytogenetic Abnormality
Anaplasia

Interacting Proteins

PCNA
POLD1
POLD3
POLD4
WRNIP1

Pathways

Dna Repair
Dna Replication
Localization
Response To Oxidative Stress
Methylation
Regulation Of Dna Repair
Dedifferentiation

Sos Response
Chromatin Remodeling

PTMs

Methylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POLD2

References

PMID: 8530069 by Zhang J., et al. Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2).

PMID: 10978529 by Perez A., et al. Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta.