Poly(U)-binding-splicing factor PUF60 (PUF60)

DNA- and RNA-binding protein, involved in a number of nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription element.

Acts as a transcriptional repressor through the core-TFIIH basal transcription element. Represses FUBP1-induced transcriptional activation but not basal transcription.