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- Table of Contents
Facts about Ras-related protein Ral-A.
Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108).
| Human | |
|---|---|
| Gene Name: | RALA |
| Uniprot: | P11233 |
| Entrez: | 5898 |

| Belongs to: |
|---|
| small GTPase superfamily |

RalA; Rasl1
Mass (kDA):
23.567 kDA

| Human | |
|---|---|
| Location: | 7p14.1 |
| Sequence: | 7; NC_000007.14 (39622955..39708124) |
Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody, Midbody ring. Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles (PubMed:19306925). May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214). However, localization at the midbody at late cytokinesis was not confirmed (PubMed:18756269).





PMID: 2662142 by Chardin P., et al. Coding sequences of human ralA and ralB cDNAs.
PMID: 2550440 by Polakis P.G., et al. Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets.