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- Table of Contents
Facts about Ral guanine nucleotide dissociation stimulator.
Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases.
Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap..
Human | |
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Gene Name: | RALGDS |
Uniprot: | Q12967 |
Entrez: | 5900 |
Belongs to: |
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No superfamily |
Ral guanine nucleotide dissociation stimulator
Mass (kDA):
100.607 kDA
Human | |
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Location: | 9q34.13-q34.2 |
Sequence: | 9; NC_000009.12 (133097722..133149210, complement) |
Cytoplasm. Nucleus. Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus.
PMID: 9365783 by Humphrey D., et al. Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1.
PMID: 7972015 by Hofer F., et al. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.