SMG1 Antibodies

AND SMG1 ELISA kits, SMG1 Proteins

Many biological assays use antibodies to detect SMG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMG1 antibodies...

We validate the specificity of these antibodies to SMG1 by testing them on tissues known to express SMG1 positively and negatively. Browse below to find the SMG1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMG1 Infographic by Boster Bio

All SMG1 Products

Product

Figures

Specificity

Applications

Price

Anti-Smg1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M02589
100 μl/vial

SMG1 Overview

Facts about Serine/threonine-protein kinase SMG1.

Serine/threonine-protein kinase SMG1 (SMG1)

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q.

Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

Gene Information

Human
Gene Name:	SMG1
Uniprot:	Q96Q15
Entrez:	23049

Family

Belongs to:

PI3/PI4-kinase family

Alternative Names

ATXserine/threonine-protein kinase SMG1; EC 2.7.11; EC 2.7.11.1; hSMG-1,61E3.4; KIAA0421phosphatidylinositol 3-kinase-related protein kinase; Lambda/iota protein kinase C-interacting protein; Lambda-interacting protein; LIPPI-3-kinase-related kinase SMG-1; phosphatidylinositol 3-kinase-related kinase; SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans); SMG-1

Molecular Weight

Mass (kDA):
410.501 kDA

Genomic Context


Human

Location:	16p12.3
Sequence:	16; NC_000016.10 (18804858..18926428, complement)

Tissue Specificity

Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver.

Subcellular Localizations

Nucleus. Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Ataxia Telangiectasia
Genotoxic Stress
Infection By Cryptococcus Neoformans
Ataxia
Telangiectasis
Chromosomal Translocation
Oropharyngeal Disorders
Neoplasm Metastasis
Congenital Muscular Dystrophy (disorder)
Tumor Progression

Head And Neck Carcinoma
Hypoxia
Malignant Neoplasm Of Lung
Malignant Tumor Of Cervix
Carcinoma
Leukemia, Myelocytic, Acute
Osteosarcoma

Interacting Proteins

PABPC1
UPF2

Pathways

Translation
Rna Surveillance
Cell Cycle
Telomere Maintenance
Cell Death
Dna Repair
Immune Response
Proteolysis
Meiosis
Cell Proliferation
S Phase
Cell Adhesion
Programmed Cell Death

Regulation Of Gene Expression
Virulence
Nuclear Export
Cell Cycle Arrest
Response To Oxidative Stress
Reverse Transcription
Mrna Splicing

PTMs

Phosphorylation
Methylation

Oxidation
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMG1

References

PMID: 9566925 by Sanchez P., et al. Localization of atypical protein kinase C isoforms into lysosome- targeted endosomes through interaction with p62.

PMID: 11544179 by Yamashita A., et al. Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.