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- Table of Contents
SMG1 Antibodies
AND SMG1 ELISA kits, SMG1 Proteins
Many biological assays use antibodies to detect SMG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMG1 antibodies...
Designing a Western blot for SMG1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SMG1 Western Blot GuideSMG1 Infographic by Boster Bio
All SMG1 Products
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SMG1 Overview
Facts about Serine/threonine-protein kinase SMG1.
Serine/threonine-protein kinase SMG1 (SMG1)
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q.
Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMG1 |
| Uniprot: | Q96Q15 |
| Entrez: | 23049 |
Family
| Belongs to: |
|---|
| PI3/PI4-kinase family |
Alternative Names
ATXserine/threonine-protein kinase SMG1; EC 2.7.11; EC 2.7.11.1; hSMG-1,61E3.4; KIAA0421phosphatidylinositol 3-kinase-related protein kinase; Lambda/iota protein kinase C-interacting protein; Lambda-interacting protein; LIPPI-3-kinase-related kinase SMG-1; phosphatidylinositol 3-kinase-related kinase; SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans); SMG-1
Molecular Weight
Mass (kDA):
410.501 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p12.3 |
| Sequence: | 16; NC_000016.10 (18804858..18926428, complement) |
Tissue Specificity
Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Ataxia Telangiectasia
- Genotoxic Stress
- Infection By Cryptococcus Neoformans
- Ataxia
- Telangiectasis
- Chromosomal Translocation
- Oropharyngeal Disorders
- Neoplasm Metastasis
- Congenital Muscular Dystrophy (disorder)
- Tumor Progression
Interacting Proteins
- PABPC1
- UPF2
Pathways
- Translation
- Rna Surveillance
- Cell Cycle
- Telomere Maintenance
- Cell Death
- Dna Repair
- Immune Response
- Proteolysis
- Meiosis
- Cell Proliferation
- S Phase
- Cell Adhesion
- Programmed Cell Death
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMG1
bosterbio.com/bosterbio-gene-info-cards/SMG1
References
PMID: 9566925 by Sanchez P., et al. Localization of atypical protein kinase C isoforms into lysosome- targeted endosomes through interaction with p62.
PMID: 11544179 by Yamashita A., et al. Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.