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- Table of Contents
Facts about F-box-like/WD repeat-containing protein TBL1XR1.
Probably acts as integral part of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, resulting in the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. .
Human | |
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Gene Name: | TBL1XR1 |
Uniprot: | Q9BZK7 |
Entrez: | 79718 |
Belongs to: |
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WD repeat EBI family |
C21; DC42; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; IRA1Transducin beta-like 1X-related protein 1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; nuclear receptor co-repressor/HDAC3 complex subunit; TBLR1TBL1-related protein 1; transducin (beta)-like 1 X-linked receptor 1; transducin (beta)-like 1X-linked receptor 1
Mass (kDA):
55.595 kDA
Human | |
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Location: | 3q26.32 |
Sequence: | 3; NC_000003.12 (177019344..177197482, complement) |
Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.
Nucleus.
PMID: 11931768 by Zhang J., et al. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.
PMID: 11063877 by Zhang X., et al. Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors.