F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors.

Probably acts as integral part of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, resulting in the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. .