TNFRSF14 Antibodies

Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)

Receptor for BTLA.

Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha.

Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of numerous wild-type HSV strains of both serotypes to CHO cells, and mediated HSV entry into activated human T-cells.

Gene Information

Human
Gene Name:	TNFRSF14
Uniprot:	Q92956
Entrez:	8764

Family

Belongs to:
tumor necrosis factor receptor superfamily

Alternative Names

ATAR; CD270 antigen; CD270; CD40-like protein; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; HVEM; HVEMTR2HVEAATAR; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entrymediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2

Molecular Weight

Mass (kDA):
30.392 kDA

Genomic Context

Human
Location:	1p36.32
Sequence:	1; NC_000001.11 (2556365..2565622)

Tissue Specificity

Widely expressed, with the highest expression in lung, spleen and thymus.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Inflammation
• Neoplasms
• Arthritis
• Rheumatoid Arthritis
• Autoimmune Reaction
• Autoimmune Diseases
• Tissue Adhesions
• Malignant Neoplasms
• Lymphoma
• Herpes Simplex Infections
• Pseudorabies
• Autoimmunity

• Dental Plaque
• Graft-vs-host Disease
• B-cell Lymphomas
• Intestinal Diseases
• Lymphoma, Follicular
• Infective Disorder
• Herpesviridae Infections

Interacting Proteins

• TNFSF14
• TRAF2
• TRAF5

Pathways

• Pathogenesis
• Immune Response
• Cell Activation
• T Cell Activation
• Cell Proliferation
• T Cell Proliferation
• Secretion
• Lymphocyte Activation
• Cytokine Production
• Cell Death
• Viral Replication
• Cell Maturation
• Membrane Fusion

• Cell Adhesion
• Transport
• Cytokine Secretion
• Tropism
• Translation
• Endocytosis
• Leukocyte Differentiation

PTMs

• Phosphorylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFRSF14

Best Uses Of The TNFRSF14 Marker

In this article, we will go over the best uses of the TNFRSF14 marker and provide Boster Bio optimization tips. We will also cover gene infographics and troubleshooting guides. By using Boster Bio, you will be able to use the TNFRSF14 marker in your experiments for the best possible results. We hope this article was helpful! Have you used the TNFRSF14 marker before? What results did you achieve?

Boster Bio optimization guides

Using Boster Bio optimization guides for the TNFLSRSF14 marker can help you maximize your experiments. Each flow procedure has multiple choices for each gene or protein. These guides can also help you optimize your results by answering specific questions. The following are some of the most common errors researchers encounter during experiments. Check out these common problems and learn how to eliminate them with proper controls. Also, don't forget to check out the Boster Bio troubleshooting guides to solve your problem.

Boster Bio gene infographics

For a quick overview of each gene, you can use the gene infographics in Boster Bio. They offer basic information about each gene, and cover all genes in human and mouse. You can also search for a particular gene by typing it in the search bar. The information presented is easy to understand, even if you're not a geneticist. In the end, you should have a clear understanding of the genes in your body.

Boster Bio troubleshooting guides

While the Boster Bio technical blog has many helpful articles, there are some things you should be aware of before beginning your ELISA experiment. Saturated signals can result in a uniform response across the wells, nonspecific binding, and an unusable standard curve. To avoid these issues, always use affinity-purified antibodies. Boster antibodies are guaranteed to react with their targets. If you use a secondary antibody, it should be bovine serum, as it will be more specific.

Immunohistochemistry is a powerful method for detecting antigens in tissue sections, using the principle of antibodies binding to antigens. This method requires careful optimization of sample preparation. The guide covers antigen retrieval, fixation, and embedding, as well as the most suitable technique for each type of preserved tissue. Preserved tissues are crucial to the success of any IHC experiment, and the Boster Bio guide outlines a step-by-step process for preparing them.