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- Table of Contents
TP53-binding protein 1 Antibodies
AND TP53BP1 ELISA kits, TP53-binding protein 1 Proteins
Many biological assays use antibodies to detect TP53-binding protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TP53-binding protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TP53-binding protein 1 antibodies...
Designing a Western blot for TP53-binding protein 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TP53BP1 Western Blot GuideTP53BP1 Infographic by Boster Bio
All TP53BP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00397
100 μl
Cat # M00397
100 μl
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00397
100 μg/vial
Cat # A00397
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00397-1
100 µg/vial
Cat # A00397-1
100 µg/vial
Human
ELISA, IP, IF, WB
$146
Cat # M00397-3
20μL, 40μL, 100μL, 200μL
Cat # M00397-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2183
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2183
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1007
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1007
1 kit, containing one 96-well plate and all necessary reagents
TP53BP1 Overview
Facts about TP53-binding protein 1.
TP53-binding protein 1 (TP53BP1)
Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) through antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a vital role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306).
In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs websites (PubMed:28241136). Recruited to DSBs websites by recognizing and binding histone H2A monoubiquitinated at'Lys-15' (H2AK15Ub) and histone H4 dimethylated at'Lys-20' (H4K20me2), two histone marks that are found at DSBs websites (PubMed:23760478, PubMed:28241136, PubMed:17190600).
Gene Information
| Human | |
|---|---|
| Gene Name: | TP53BP1 |
| Uniprot: | Q12888 |
| Entrez: | 7158 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
53BP1; FLJ41424; MGC138366; p202; p53-binding protein 1; p53bp1; TP53BP1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
Molecular Weight
Mass (kDA):
213.574 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q15.3 |
| Sequence: | 15; NC_000015.10 (43403061..43510640, complement) |
Subcellular Localizations
Nucleus. Chromosome. Chromosome, centromere, kinetochore. Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Ataxia Telangiectasia
- Ataxia
- Telangiectasis
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Genomic Instability
- Cell Transformation, Neoplastic
- Carcinoma
- Cytogenetic Abnormality
- Retinoblastoma
- Exposure To Ionizing Radiation
Interacting Proteins
- ATM
- BRCA1
- H2AFX
- HIST1H3A
- HIST1H4A
- MEOX2
- MYC
- NCOA6
- PAXIP1
- Paxip1
Pathways
- Dna Repair
- Cell Cycle
- Dna Damage Checkpoint
- Cell Growth
- Dna Replication
- Localization
- Cell Proliferation
- Cell Cycle Checkpoint
- Double-strand Break Repair
- Mitosis
- Senescence
- Methylation
- Cell Death
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
- Deamination
Research Areas
- Breast Cancer
- Cancer
- Checkpoint signaling
- DNA Double Strand Break Repair
- DNA Repair
- Epigenetics
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TP53BP1
bosterbio.com/bosterbio-gene-info-cards/TP53BP1
References
PMID: 9748285 by Iwabuchi K., et al. Stimulation of p53-mediated transcriptional activation by the p53- binding proteins, 53BP1 and 53BP2.
PMID: 8016121 by Iwabuchi K., et al. Two cellular proteins that bind to wild-type but not mutant p53.