Treml4 Antibodies

AND Treml4 ELISA kits, Treml4 Proteins

Many biological assays use antibodies to detect Treml4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Treml4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Treml4 antibodies...

We validate the specificity of these antibodies to Treml4 by testing them on tissues known to express Treml4 positively and negatively. Browse below to find the Treml4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Treml4 Infographic by Boster Bio

All Treml4 Products

Product

Figures

Specificity

Applications

Price

TREML4 (NM_198153) Human Over-expression Lysate

Human

$628
Cat # LS285852
100 µg

Treml4 Overview

Facts about Trem-like transcript 4 protein.

Trem-like transcript 4 protein (Treml4)

Positively regulates Toll-like receptor signaling through TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages (PubMed:25848864). Regulates TLR7 signaling by controlling ligand- induced recruitment of TLR7 in the endoplasmic reticulum into endosomes and lysosomes (PubMed:25848864).

Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production (PubMed:25848864). Involved in the anti-viral reaction to many viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus (PubMed:25848864).

Gene Information

Mouse
Gene Name:	Treml4
Uniprot:	Q3LRV9
Entrez:	224840

Family

Belongs to:

No superfamily

Alternative Names

TLT4; TREML4

Molecular Weight

Mass (kDA):
29.355 kDA

Genomic Context


Mouse

Location:	17\|17 C
Sequence:	17;

Tissue Specificity

Predominantly expressed in spleen, with highest levels on selected populations of macrophages, including red pulp macrophages, and on subsets of dendritic cells (DC), mostly on CD8alpha(+) DC (at protein level) (PubMed:19155473, PubMed:22210914, PubMed:25848864). Also expressed on blood and spleen Ly6C(low) monocytes (at protein level) (PubMed:22210914). Not expressed on lymphocytes or granulocytes (at protein level) (PubMed:19155473, PubMed:22210914).

Diseases

Melanoma, Experimental
Malignant Neoplasms
Neoplasms
Hiv Infections
Malignant Neoplasm Of Breast

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Treml4

References

PMID: 19155473 by Hemmi H., et al. A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells.

PMID: 22210914 by Hemmi H., et al. Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.