TUFM Antibodies

AND TUFM ELISA kits, TUFM Proteins

Many biological assays use antibodies to detect TUFM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TUFM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TUFM antibodies...

We validate the specificity of these antibodies to TUFM by testing them on tissues known to express TUFM positively and negatively. Browse below to find the TUFM antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TUFM Infographic by Boster Bio

All TUFM Products

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Applications

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Anti-TUFM Antibody

1 Q&As

Western Blot analysis of various cell lysis

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$335
Cat # A30672
100ul

Anti-EF-Tu TUFM Antibody

Western blot analysis of extracts of various cell lines, using TUFM antibody at 1:1000 dilution

Immunohistochemistry of paraffin-embedded human esophageal cancer using TUFM antibody at dilution of 1:100

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$405
Cat # A05606-1
100ul

Anti-TUFM Antibody Picoband®

Western blot analysis of TUFM using anti-TUFM antibody (A05606-2)

IF analysis of TUFM using anti-TUFM antibody (A05606-2)

Human, Mouse, Rat

ELISA, IF, ICC, WB

$370
Cat # A05606-2
100 μg/vial

TUFM Overview

Facts about Elongation factor Tu, mitochondrial.

TUFM 3D structure. Source: alphafold

Elongation factor Tu, mitochondrial (TUFM)

Promotes the GTP-dependent binding of aminoacyl-tRNA into the A-site of ribosomes during protein biosynthesis. Plays also a part in the regulation of autophagy and innate immunity.

Recruits ATG5-ATG12 and NLRX1 in mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. Consequently, inhibits RLR-mediated type I interferon while promoting autophagy.

Gene Information

Human
Gene Name:	TUFM
Uniprot:	P49411
Entrez:	7284

Family

Belongs to:

TRAFAC class translation factor GTPase superfamily

Alternative Names

EFTu; EF-Tu; EFTUCOXPD4; EF-TuMT; elongation factor Tu, mitochondrial; P43; Tu translation elongation factor, mitochondrial

Molecular Weight

Mass (kDA):
49.542 kDA

Genomic Context


Human

Location:	16p11.2
Sequence:	16; NC_000016.10 (28842411..28846348, complement)

Subcellular Localizations

Mitochondrion.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Benign Neoplasm
Breast Diseases
Mitochondrial Diseases
Carcinoma
Tumor Angiogenesis
Adenocarcinoma
Acidosis
Acidosis, Lactic

Decreased Immunologic Activity [pe]
Inflammation
Colorectal Cancer
Cell Transformation, Neoplastic
Stomach Neoplasms
Neoplasm Metastasis
Adenoma

Interacting Proteins

ARL6IP1
CMTM5
FAM9B
FUNDC1
NLRX1

Pathways

Translation
Mitochondrial Translation
Angiogenesis
Autophagy
Cell Proliferation
Regulation Of Myoblast Differentiation
Macrophage Chemotaxis
Immune Response
Localization
Endothelial Cell Proliferation
Inflammatory Response
Drug Resistance
Chemotaxis

Embryo Implantation
Cell Death
Cellular Localization
Cell Differentiation
Cell Growth
Myoblast Differentiation
Lymphocyte Proliferation

PTMs

Cleavage

Deamination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TUFM

References

PMID: 8547323 by Woriax V.L., et al. Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu.

PMID: 7828719 by Wells J., et al. A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues.