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USP30 Antibodies
AND USP30 ELISA kits, USP30 Proteins
Many biological assays use antibodies to detect USP30, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP30 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP30 antibodies...
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USP30 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 30.
Ubiquitin carboxyl-terminal hydrolase 30 (USP30)
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that functions as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to induce mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves'Lys-6'- and'Lys-11'- linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951).
Does not cleave efficiently polyubiquitin phosphorylated in'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | USP30 |
| Uniprot: | Q70CQ3 |
| Entrez: | 84749 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating Enzyme 30; EC 3.1.2.15; EC 3.4.19.12; FLJ40511; MGC10702; ubiquitin carboxyl-terminal hydrolase 30; ubiquitin specific peptidase 30; ubiquitin specific protease 30; Ubiquitin Thioesterase 30; Ubiquitin thiolesterase 30; ubiquitin-specific protease 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30; USP30
Molecular Weight
Mass (kDA):
58.503 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.11 |
| Sequence: | 12; NC_000012.12 (109023089..109088026) |
Tissue Specificity
Expressed in skeletal muscle, pancreas, liver and kidney.
Subcellular Localizations
Mitochondrion outer membrane.
Diseases
- Neoplasm Metastasis
- Tissue Adhesions
Pathways
- Mitochondrial Fusion
- Cell Motility
- Oxidative Phosphorylation
- Rna Interference
- Autophagy
- Cell-cell Adhesion
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP30
bosterbio.com/bosterbio-gene-info-cards/USP30
References
PMID: 14715245 by Quesada V., et al. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.
PMID: 18287522 by Nakamura N., et al. Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane.