USP30 Antibodies

AND USP30 ELISA kits, USP30 Proteins

Many biological assays use antibodies to detect USP30, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP30 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP30 antibodies...

We validate the specificity of these antibodies to USP30 by testing them on tissues known to express USP30 positively and negatively. Browse below to find the USP30 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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USP30 Infographic by Boster Bio

All USP30 Products

Product

Figures

Specificity

Applications

Price

Anti-USP30 Antibody

5 Q&As

Human, Mouse, Rat

ELISA, WB

$399
Cat # A06403-1
100μl

USP30 (NM_032663) Human Over-expression Lysate

Human

$628
Cat # LS084749
100 µg

USP30 Overview

Facts about Ubiquitin carboxyl-terminal hydrolase 30.

USP30 3D structure. Source: alphafold

Ubiquitin carboxyl-terminal hydrolase 30 (USP30)

Deubiquitinating enzyme tethered to the mitochondrial outer membrane that functions as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to induce mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves'Lys-6'- and'Lys-11'- linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951).

Does not cleave efficiently polyubiquitin phosphorylated in'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).

Gene Information

Human
Gene Name:	USP30
Uniprot:	Q70CQ3
Entrez:	84749

Family

Belongs to:

peptidase C19 family

Alternative Names

Deubiquitinating Enzyme 30; EC 3.1.2.15; EC 3.4.19.12; FLJ40511; MGC10702; ubiquitin carboxyl-terminal hydrolase 30; ubiquitin specific peptidase 30; ubiquitin specific protease 30; Ubiquitin Thioesterase 30; Ubiquitin thiolesterase 30; ubiquitin-specific protease 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30; USP30

Molecular Weight

Mass (kDA):
58.503 kDA

Genomic Context


Human

Location:	12q24.11
Sequence:	12; NC_000012.12 (109023089..109088026)

Tissue Specificity

Expressed in skeletal muscle, pancreas, liver and kidney.

Subcellular Localizations

Mitochondrion outer membrane.

Diseases

Neoplasm Metastasis
Tissue Adhesions

Pathways

Mitochondrial Fusion
Cell Motility
Oxidative Phosphorylation
Rna Interference
Autophagy
Cell-cell Adhesion

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP30

References

PMID: 14715245 by Quesada V., et al. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

PMID: 18287522 by Nakamura N., et al. Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane.