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- Table of Contents
VAV3 Antibodies
AND VAV3 ELISA kits, VAV3 Proteins
Many biological assays use antibodies to detect VAV3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VAV3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VAV3 antibodies...
Designing a Western blot for VAV3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the VAV3 Western Blot GuideVAV3 Infographic by Boster Bio
All VAV3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M03204
100 μl/vial
Cat # M03204
100 μl/vial
Human, Mouse
ELISA
$480
Cat # EKC1591
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1591
1 kit, containing one 96-well plate and all necessary reagents
VAV3 Overview
Facts about Guanine nucleotide exchange factor VAV3.
Guanine nucleotide exchange factor VAV3 (VAV3)
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically into the nucleotide-free states of these GTPases.
Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is vital for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | VAV3 |
| Uniprot: | Q9UKW4 |
| Entrez: | 10451 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ40431; guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
Molecular Weight
Mass (kDA):
97.776 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.3 |
| Sequence: | 1; NC_000001.11 (107571161..107965180, complement) |
Tissue Specificity
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Hypertensive Disease
- Neoplasm Metastasis
- Osteoporosis
- Tumor Angiogenesis
Interacting Proteins
- GAB1
- GRB2
- MET
- PIK3R1
Pathways
- Pathogenesis
- Cell Migration
- Phagocytosis
- Localization
- Bone Resorption
- Cell Cycle
- Cell Proliferation
- Cell Growth
- Cell Adhesion
- Cell Activation
- Angiogenesis
- T Cell Activation
- Platelet Activation
PTMs
- Phosphorylation
- Methylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VAV3
bosterbio.com/bosterbio-gene-info-cards/VAV3
References
PMID: 9705494 by Trenkle T., et al. Non-stoichiometric reduced complexity probes for cDNA arrays.
PMID: 10523675 by Movilla N., et al. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins.