Vacuolar protein sorting-associated protein 4A (VPS4A)

Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III elements to the cytoplasm for further rounds of MVB sorting.

MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are usually delivered to lysosomes allowing degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In combination with the ESCRT machinery also seems to function in topologically equivalent membrane fission events, like the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).