- Table of Contents
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are a subpopulation of cancer cells that possess the self-renewal and multi/pluripotency properties similar to that of normal stem cells. They have been identified to be tumorigenic and linked with inducing metastasis. Several molecular signaling pathways are associated with governing stem cell homeostasis. Normally, these pathways are highly regulated. However, an increasing number of these signaling pathways have been discovered to become dysfunctional in CSCs, which include the JAK/STAT, Hedgehog, Wnt, Notch, NF-κB, PI3K and PTEN signaling pathways. In certain cases, cross-talk between different pathways contribute to CSC population maintenance.
Click below to download the PDF poster. Or scroll further to browse our entire Pathway Maps catalog online!Download Now
Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.Troubleshooting guides
Get better results with Boster!
Boster takes great measures to ensure product quality and to provide our customers with comprehensive data upfront. Our antibodies are validated using WB, IHC, and flow cytometry against a panel of over 250 tissues and un-transfected cell lines to ensure high affinity and crystal-clear IHC stains. In addition, we also validate our antibodies in a quantitative fashion by testing them on known quantities of recombinant proteins so that you know what to expect (e.g. if there is 1ng, 2.5ng or 5ng of the target protein in the sample). Every product is covered by the Boster Quality Guarantee, click below to learn more.
Have questions? We're here to help.