Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody
Rabbit IgG polyclonal antibody for B-cell lymphoma/leukemia 10(BCL10) detection. Tested with WB in Human;Mouse;Rat.
Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody
See all Bcl-10 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Bcl-10/BCL10 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Bcl-10/BCL10 information: Molecular Weight: 26252 MW; Subcellular Localization: Cytoplasm, perinuclear region . Membrane raft . Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts; Tissue Specificity: Ubiquitous.|
|Cite This Product||Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1504)|
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|Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody may replace the following items: sc 9558|sc 55511|sc 5611|sc 9560|sc 13153|sc 32808|sc 5273|sc 56023.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human Bcl10(35-51aa ERHFDHLRAKKILSRED), identical to the related rat and mouse sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For BCL10 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||8915|
|Species Of This Entry||Human|
|Protein Name||B-cell lymphoma/leukemia 10|
|Alternative Names||Bcl-10|B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10; Bcl10; Bcl-10; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; c-E10; c-E10bcl-10; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; cellular-E10; CIPER; CLAP; hCLAP; Mammalian CARD-containing adapter molecule E10; mE10; mE10CARD containing molecule enhancing NF-kB|
|Post Tranlational Modifications||Phosphorylation; Ubiquitination; Cleavage; Dephosphorylation; Methylation; Biotinylation; Deamidation|
|Subcellular Localization||Cytoplasm, perinuclear region. Membrane raft. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.|
|Gene Location||1p22.3, on Chromasome 1, gene sequence: NC_000001.11 (85265776..85276632, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For BCL10 (Source: Uniprot.org, NCBI)
|Protein Function||Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).|
|Interacting Proteins||AKT1; BCL3; CARD11; CARD9; COG6; IKBKG; MALT1; PRKCZ; TRAF2|
|Research Areas||Apoptosis; Cancer|
|Related Diseases||Lymphoma; Mucosa-associated Lymphoid Tissue Lymphoma; Marginal Zone B-cell Lymphoma; Neoplasms; B-cell Lymphomas; Chromosomal Translocation; Malignant Neoplasms; T(11;18)(q21;q21); Diffuse Large B-cell Lymphoma; Stomach Neoplasms; Inflammation; Carcinoma; Malignant Paraganglionic Neoplasm; Gastric Mucosa-associated Lymphoid Tissue Lymphoma; Cytogenetic Abnormality; Cell Transformation, Neoplastic; Helicobacter Infections; Lymphoma, Non-hodgkin; Leukemogenesis|
|Related Pathways||Pathogenesis; Cell Activation; Cytokine Production; Immune Response; T Cell Activation; Secretion; Localization; Lymphocyte Activation; Cell Death; Adaptive Immune Response; Interphase; Cell Proliferation; Rna Interference; Cell Cycle; Inflammatory Response; Lymphocyte Proliferation; Cell Growth; Mismatch Repair; Phagocytosis; Translation|
|Background||BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue(MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain(CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are though to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are though to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.|
|Scientific References||PMID: 9989495 by Willis T.G., et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.|
PMID: 10187770 by Koseki T., et al. CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10.
Our Boster Quality Guarantee for Anti-B-cell lymphoma/leukemia 10 Bcl10 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
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