Product Info Summary
SKU: | A02803Y121 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-Cyclophilin F (Y121) PPIF Antibody
View all Cyclophilin-F Antibodies
SKU/Catalog Number
A02803Y121
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Cyclophilin F (Y121) PPIF Antibody catalog # A02803Y121. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Cyclophilin F (Y121) PPIF Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02803Y121)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human PPIF.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02803Y121 is reactive to PPIF in Human, Mouse, Rat
Applications
A02803Y121 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
22.04kDa
Background of Cyclophilin-F
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Bergsma D.J., J. Biol. Chem. 266:23204-23214(1991).
Deloukas P., Nature 429:375-381(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
IHC: 1:50-1:200
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For PPIF (Source: Uniprot.org, NCBI)
Gene Name
PPIF
Full Name
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Weight
22.04kDa
Superfamily
cyclophilin-type PPIase family
Alternative Names
Cyclophilin F; CYP3FLJ90798; Cyp-D; hCyP3; MGC117207; mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; peptidylprolyl isomerase F (cyclophilin F); peptidylprolyl isomerase F PPIF CYP3, CyP-M, Cyp-D, CypD peptidylprolyl isomerase F peptidyl-prolyl cis-trans isomerase F, mitochondrial|PPIase F|cyclophilin 3|cyclophilin D|cyclophilin F|mitochondrial cyclophilin|peptidyl-prolyl cis-trans isomerase, mitochondrial|rotamase F
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PPIF, check out the PPIF Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PPIF: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cyclophilin F (Y121) PPIF Antibody (A02803Y121)
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