Product Info Summary
SKU: | A11563 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Chicken |
Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-ECRG2 SPINK7 Antibody
SKU/Catalog Number
A11563
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ECRG2 SPINK7 Antibody (Catalog # A11563). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
ECRG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ECRG2 SPINK7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11563)
Host
Chicken
Contents
ECRG2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgY
Immunogen
ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2. The immunogen is located within the last 50 amino acids of ECRG2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ECRG2 antibody is predicted to not cross-react with other ECRG family members
Reactive Species
A11563 is reactive to SPINK7 in Human, Mouse, Rat
Applications
A11563 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
9.232kDa
Background of SPINK7
The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ECRG2 antibody can be used for detection of ECRG2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of ECRG2 in A-20 cell lysate with ECRG2 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.
Click image to see more details
Immunohistochemistry of ECRG2 in rat lung tissue with ECRG2 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SPINK7 (Source: Uniprot.org, NCBI)
Gene Name
SPINK7
Full Name
Serine protease inhibitor Kazal-type 7
Weight
9.232kDa
Alternative Names
Serine protease inhibitor Kazal-type 7 SPINK7 ECG2, ECRG2 serine peptidase inhibitor Kazal type 7 serine protease inhibitor Kazal-type 7|ECRG-2|esophagus cancer-related gene 2 protein|esophagus cancer-related gene-2|serine peptidase inhibitor, Kazal type 7 (putative)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SPINK7, check out the SPINK7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SPINK7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ECRG2 SPINK7 Antibody (A11563)
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No publications found for A11563
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Customer Reviews
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