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Product Info Summary
| SKU: | M07091-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Primate |
| Host: | Mouse |
| Application: | Flow Cytometry, IP, IHC-F, WB |
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Product info
Product Name
Anti-Hu CD103 Purified ITGAE Monoclonal Antibody
SKU/Catalog Number
M07091-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD103 Purified ITGAE Monoclonal Antibody (Catalog# M07091-1). Tested in Flow Cytometry, IP, WB, IHC-F application(s). This antibody reacts with Human, Primate.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD103 Purified ITGAE Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M07091-1)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
Ber-ACT8
Isotype
Mouse IgG1 kappa
Immunogen
HTLV-1 induced human T cell line MAPS16. The mouse monoclonal antibody Ber-ACT8 recognizes an extracellular epitope of CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
As in case with other anti-CD170 antibodies, this antibody cross-reacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
Reactive Species
M07091-1 is reactive to ITGAE in Human, Primate
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
130159 MW
Background of ITGAE
CD103 / integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M07091-1 is guaranteed for Flow Cytometry, IP, IHC-F, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 μg/ml.
Validation Images & Assay Conditions
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Protein Target Info & Infographic
Gene/Protein Information For ITGAE (Source: Uniprot.org, NCBI)
Gene Name
ITGAE
Full Name
Integrin alpha-E
Weight
130159 MW
Superfamily
integrin alpha chain family
Alternative Names
Integrin alpha E, ITGAE ITGAE CD103, HUMINAE integrin subunit alpha E integrin alpha-E|HML-1 | CD103, human mucosal lymphocyte 1; alpha polypeptide|human mucosal lymphocyte 1, alpha polypeptide|integrin alpha-IEL|integrin, alpha E ( CD103, human mucosal lymphocyte 1; alpha polypeptide)|mucosal lymphocyte 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ITGAE, check out the ITGAE Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ITGAE: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Hu CD103 Purified ITGAE Monoclonal Antibody (M07091-1)
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