Anti-Hu CD105 Purified ENG Monoclonal Antibody

Endoglin/CD105 antibody

Boster Bio Anti-Hu CD105 Purified ENG Monoclonal Antibody (Catalog# M02997-1). Tested in Flow Cytometry, IP, WB, MC (CyTOF) application(s). This antibody reacts with Rat, Human.

Product Info Summary

SKU: M02997-1
Size: 0.1 mg
Reactive Species: Human, Rat
Host: Mouse
Application: Flow Cytometry, IP, WB, CyTOF

Product Name

Anti-Hu CD105 Purified ENG Monoclonal Antibody

View all Endoglin/CD105 Antibodies

SKU/Catalog Number

M02997-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD105 Purified ENG Monoclonal Antibody (Catalog# M02997-1). Tested in Flow Cytometry, IP, WB, MC (CyTOF) application(s). This antibody reacts with Rat, Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD105 Purified ENG Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02997-1)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

MEM-226

Isotype

Mouse IgG2a

Immunogen

Recombinant Vaccinia virus containing the human CD105 cDNA. The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

This antibody does not cross-react with Thy-1.1 alloantigen.

Reactive Species

M02997-1 is reactive to ENG in Human, Rat

Applications

M02997-1 is guaranteed for Flow Cytometry, IP, WB, CyTOF Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

70.578kDa

Background of Endoglin/CD105

CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1-5 μg/ml.
Western blotting: Non-reducing conditions.

Validation Images & Assay Conditions

Gene/Protein Information For ENG (Source: Uniprot.org, NCBI)

Gene Name

ENG

Full Name

Endoglin

Weight

70.578kDa

Alternative Names

CD105 antigen; CD105; Endoglin; ENDOsler-Rendu-Weber syndrome 1; ENG; HHT1FLJ41744; ORW; ORW1 ENG END, HHT1, ORW1 endoglin endoglin|CD105 antigen

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ENG, check out the ENG Infographic

ENG infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ENG: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M02997-1

0.1 mg

$298

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
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