Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody

Product Name

Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody

View all KLRB1 Antibodies

SKU/Catalog Number

M03917-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody (Catalog# M03917-1). Tested in Flow Cytometry, WB, IHC-F application(s). This antibody reacts with Primate, Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M03917-1)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

HP-3G10

Isotype

Mouse IgG1 kappa

Immunogen

Human NK cells. The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.

Cross-reactivity

This antibody does not cross-react with Thy-1.1 alloantigen.

Reactive Species

M03917-1 is reactive to KLRB1 in Human, Primate

Observed Molecular Weight

42 kDa

Calculated molecular weight

25.4 kDa

Background of KLRB1

CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M03917-1 is guaranteed for Flow Cytometry, IHC-F, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1-4 μg/ml.

Validation Images & Assay Conditions

See full target information KLRB1

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