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Product Info Summary
| SKU: | M02496-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Mouse |
| Application: | Flow Cytometry, IP, ICC, WB |
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Product info
Product Name
Anti-NTAL Purified Lat2 Monoclonal Antibody
SKU/Catalog Number
M02496-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NTAL Purified Lat2 Monoclonal Antibody (Catalog# M02496-1). Tested in Flow Cytometry, IP, WB, ICC application(s). This antibody reacts with Human, Mouse.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-NTAL Purified Lat2 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02496-1)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
NAP-07
Isotype
Mouse IgG1
Immunogen
Recombinant cytoplasmic domain (aa 91-243) of human NTAL. The antibody NAP-07 reacts with an intracellular epitope of Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B lymphocytes, NK cells and myeloid cells.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody does not cross-react with Thy-1.1 alloantigen.
Reactive Species
M02496-1 is reactive to LAT2 in Human, Mouse
Applications
M02496-1 is guaranteed for Flow Cytometry, IP, ICC, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
26.55kDa
Background of NTAL
NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1-2 μg/ml.
Flow cytometry: Intracellular staining; recommended dilution: 1-4 µg/ml; positive tissue: RAJI human lymphoma cell line, RAMOS human lymphoma cell line.
Validation Images & Assay Conditions
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Figure 1. Immunocytochemistry staining of Lat2 using Anti-NTAL Purified Lat2 Monoclonal Antibody (M02496-1).
Immunocytochemistry analysis of NTAL by confocal microscopy in THP-1 human acute monocytic leukemia cell line. The cells were permeabilized and immunostained using anti-NTAL (NAP-07; green). Nuclei are vizualized by propidium iodide (red).Protein Target Info & Infographic
Gene/Protein Information For LAT2 (Source: Uniprot.org, NCBI)
Gene Name
LAT2
Full Name
Linker for activation of T-cells family member 2
Weight
26.55kDa
Alternative Names
LAB; LABWilliams-Beuren syndrome chromosomal region 15 protein; Linker for activation of B-cells; linker for activation of T cells family, member 2; linker for activation of T-cells family member 2; Membrane-associated adapter molecule; Non-T-cell activation linker; NTAL; NTALWilliams-Beuren syndrome chromosomal region 5 protein; WBS15; WBSCR15; WBSCR5; WBSCR5HSPC046; Williams-Beuren syndrome chromosome region 5; WSCR5 LAT2 HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5 linker for activation of T cells family member 2 linker for activation of T-cells family member 2|Williams-Beuren syndrome chromosomal region 15 protein|Williams-Beuren syndrome chromosomal region 5 protein|linker for activation of B-cells|linker for activation of T cells, transmembrane adaptor 2|membrane-associated adapter molecule|non-T-cell activation linker
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LAT2, check out the LAT2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LAT2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NTAL Purified Lat2 Monoclonal Antibody (M02496-1)
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