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- Table of Contents
KHDRBS1 Antibodies
AND KHDRBS1 ELISA kits, KHDRBS1 Proteins
Many biological assays use antibodies to detect KHDRBS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KHDRBS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KHDRBS1 antibodies...
Designing an IHC experiment for KHDRBS1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the KHDRBS1 IHC GuideKHDRBS1 Infographic by Boster Bio
All KHDRBS1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01717-1
100 µg/vial
Cat # A01717-1
100 µg/vial
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01717-2
100 μl/vial
Cat # M01717-2
100 μl/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01717-1
100 μl/vial
Cat # M01717-1
100 μl/vial
Human
ELISA
$540
Cat # EKC2193
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2193
1 kit, containing two 96-well plates and all necessary reagents
KHDRBS1 Overview
Facts about KH domain-containing, RNA-binding, signal transduction-associated protein 1.
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)
Recruited and tyrosine phosphorylated by various receptor systems, for instance the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins.
Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also functions as a putative regulator of mRNA stability and/or translation speeds and mediates mRNA nuclear export.
Gene Information
| Human | |
|---|---|
| Gene Name: | KHDRBS1 |
| Uniprot: | Q07666 |
| Entrez: | 10657 |
Family
| Belongs to: |
|---|
| KHDRBS family |
Alternative Names
FLJ34027; GAP-associated tyrosine phosphoprotein p62; KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KHDRBS1; p21 Ras GTPase-activating protein-associated p62; p62; p68; SAM68; Sam68GAP-associated tyrosine phosphoprotein p62 (Sam68); Src-associated in mitosis 68 kDa protein
Molecular Weight
Mass (kDA):
48.227 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p35.2 |
| Sequence: | 1; NC_000001.11 (32013868..32060850) |
Tissue Specificity
Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.
Subcellular Localizations
Nucleus. Cytoplasm. Membrane. Predominantly located in the nucleus but also located partially in the cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Hiv Infections
- Mammary Neoplasms
- Immunologic Deficiency Syndromes
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Carcinoma
- Neoplasm Metastasis
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Infertility
Interacting Proteins
- APC
- FYN
- GRB2
- HCK
- HNRNPA1
- HNRNPK
- JAK3
- LCK
- Lck
- PLCG1
Pathways
- Mitosis
- Localization
- Translation
- Cell Cycle
- Cell Proliferation
- Nuclear Export
- Rna Processing
- Rna Splicing
- Methylation
- Spermatogenesis
- Transport
- Cell Migration
- Meiosis
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KHDRBS1
bosterbio.com/bosterbio-gene-info-cards/KHDRBS1
References
PMID: 1374686 by Wong G., et al. Molecular cloning and nucleic acid binding properties of the GAP- associated tyrosine phosphoprotein p62.
PMID: 9013542 by Barlat I., et al. A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain.