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- Table of Contents
SPARC Antibodies
AND SPARC ELISA kits, SPARC Proteins
Many biological assays use antibodies to detect SPARC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPARC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPARC antibodies...
Designing a Western blot for SPARC? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SPARC Western Blot GuideSPARC Infographic by Boster Bio
All SPARC Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00863
100 μg/vial
Cat # A00863
100 μg/vial
Human
ELISA
$499
Cat # EK1309
96 wells/kit, with removable strips.
Cat # EK1309
96 wells/kit, with removable strips.
Human
ELISA
$750
Cat # EK1848
96 wells/kit, with removable strips.
Cat # EK1848
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK2125
96 wells/kit, with removable strips.
Cat # EK2125
96 wells/kit, with removable strips.
Human, Mouse, Rat
IHC, WB
$370
Cat # PA2088
100 μg/vial
Cat # PA2088
100 μg/vial
SPARC Overview
Facts about SPARC.
SPARC
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds magnesium and calcium, several kinds of collagen, albumin, thrombospondin, PDGF and cell membranes.
There are two calcium binding sites; an acidic domain that binds 5 to 2 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SPARC |
| Uniprot: | P09486 |
| Entrez: | 6678 |
Family
| Belongs to: |
|---|
| SPARC family |
Alternative Names
Basement-membrane protein 40; BM-40; ONcysteine-rich protein; Osteonectin; Secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin); SPARC
Molecular Weight
Mass (kDA):
34.632 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.1 |
| Sequence: | 5; NC_000005.10 (151661096..151686915, complement) |
Subcellular Localizations
Secreted, extracellular space, extracellular matrix, basement membrane. In or around the basement membrane.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Tumor Angiogenesis
- Carcinoma
- Cell Invasion
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Fibrosis
- Neoplasm Invasiveness
- Pathologic Neovascularization
- Cell Transformation, Neoplastic
Interacting Proteins
- MYOC
Pathways
- Angiogenesis
- Cell Proliferation
- Cell Adhesion
- Secretion
- Localization
- Cell Cycle
- Cell Migration
- Pathogenesis
- Wound Healing
- Cell Growth
- Methylation
- Tissue Remodeling
- Transport
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Glycosylation
- Reduction
- Demethylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPARC
bosterbio.com/bosterbio-gene-info-cards/SPARC
References
PMID: 3410046 by Lankat-Buttgereit B., et al. Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin).
PMID: 2838412 by Swaroop A., et al. Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31- q33.
8 Publications of Boster SPARC Antibodies & ELISA Kits
- PubMed ID: 10.3109/13880209.2015.1017885, Anti-osteoporotic activity of puerarin 6″-O-xyloside on ovariectomized mice an...
- PubMed ID: 10.1152/ajprenal.00225.2016, 4-PBA improves lithium-induced nephrogenic diabetes insipidus by attenuating ER ...
- PubMed ID: 10.1039/C5TB01956G, Alendronate-loaded hydroxyapatite-TiO2 nanotubes for improved bone formation in ...
- PubMed ID: 10.1016/j.lfs.2018.11.062, Effects of sprint interval or combined aerobic and resistance training on myokin...
- PubMed ID: 10.1007/s12195-012-0244-9, Effects of Phytoestrogen α-ZAL and Mechanical Stimulation on Proliferation, Ost...
- PubMed ID: 26329007, CD90 is upregulated in gastric cancer tissues and inhibits gastric cancer cell a...
- PubMed ID: 22099899, Tang Y, Sun F, Li X, Zhou Y, Yin S, Zhou X. J Endod. 2011 Dec;37(12):1653-8. Doi...
- PubMed ID: 24853718, Zhao H, Ning Ll, Wang Zy, Li Ht, Qiao D, Yao Y, Qin Hl. Cell Biochem Biophys. 20...
*More publications can be found for each product on its corresponding product page