Abcg5 Antibodies

ATP-binding cassette sub-family G member 5 (Abcg5)

ABCG5 and ABCG8 form an obligate heterodimer which mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an important role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion from the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:19846887, PubMed:25378657).

Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG8 has ATPase activity (PubMed:16352607, PubMed:16867993).

Gene Information

Mouse
Gene Name:	Abcg5
Uniprot:	Q99PE8
Entrez:	27409

Family

Belongs to:
ABC transporter superfamily

Alternative Names

ATP-binding cassette sub-family G member 5; ATP-binding cassette, sub-family G (WHITE), member 5; ATP-binding cassette, subfamily G, member 5; sterolin 1; sterolin-1; STSL

Molecular Weight

Mass (kDA):
73.244 kDA

Genomic Context

Mouse
Location:	17 E4|17 55.02 cM
Sequence:	17;

Tissue Specificity

Detected in liver and jejunum (PubMed:12444248, PubMed:15040800, PubMed:18402465, PubMed:25378657). Detected on enterocyte villi (at protein level) (PubMed:15040800). Expressed in jejunum, ileum and, at lower level, in the liver (PubMed:11138003, PubMed:11907139, PubMed:11099417, PubMed:12444248, PubMed:25378657).

Diseases

• Sitosterolemia
• Hypercholesterolemia
• Atherosclerosis
• Cholecystolithiasis
• Cardiovascular Diseases
• Insulin Resistance
• Malignant Neoplasms
• Inflammation
• Hyperlipidemia
• Xanthoma
• Heart Diseases
• Coronary Heart Disease

• Diabetes Mellitus
• Obesity
• Dyslipidemias
• Cholestasis
• Arteriosclerosis
• Coronary Artery Disease
• Cholelithiasis

Pathways

• Transport
• Secretion
• Excretion
• Cholesterol Transport
• Intestinal Cholesterol Absorption
• Cholesterol Homeostasis
• Intestinal Absorption
• Reverse Cholesterol Transport
• Cholesterol Efflux
• Gallstone Formation
• Sterol Transport
• Lipid Transport
• Localization

• Lipid Homeostasis
• Pathogenesis
• Regulation Of Intestinal Cholesterol Absorption
• Cholesterol Esterification
• Bile Acid Secretion
• Acid Secretion
• Sterol Homeostasis

PTMs

• Phosphorylation
• Oxidation
• Cleavage
• Glycosylation

• Methylation
• Reduction
• Acetylation
• Palmitoylation

• Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Abcg5

Boster Bio: Best Uses Of The ABCG5 Marker

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