ATP-binding cassette sub-family G member 5 (Abcg5)

ABCG5 and ABCG8 form an obligate heterodimer which mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an important role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion from the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:19846887, PubMed:25378657).

Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG8 has ATPase activity (PubMed:16352607, PubMed:16867993).