Abl interactor 2 (ABI2)

Regulator of actin cytoskeleton dynamics inherent cell motility and adhesion. Functions as a part of the WAVE complex, which triggers actin nucleating machinery Arp2/3 to induce lamellipodia formation (PubMed:21107423).

Positively regulates ABL1-mediated phosphorylation of ENAH, which is needed for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections.