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- Table of Contents
Facts about Abl interactor 2.
Positively regulates ABL1-mediated phosphorylation of ENAH, which is needed for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections.
Human | |
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Gene Name: | ABI2 |
Uniprot: | Q9NYB9 |
Entrez: | 10152 |
Belongs to: |
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ABI family |
Abelson interactor 2; Abi-2; ABI2B; abl binding protein 3; abl interactor 2; Abl-binding protein 3; AblBP3ABI-2; abl-interacting protein 1 (SH3-containing protein); abl-interactor 2; abl-interactor protein 2b; AIP-1; arg protein tyrosine kinase-binding protein; Arg-binding protein 1; argBP1; argBPIA; argBPIB; SSH3BP2
Mass (kDA):
55.663 kDA
Human | |
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Location: | 2q33.2 |
Sequence: | 2; NC_000002.12 (203325013..203432169) |
Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
Cytoplasm. Nucleus.; [Isoform 1]: Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips (PubMed:11516653, PubMed:15572692). Present at nascent adherens junctions, where it clusters adjacent to the tips of F-actin protrusions (PubMed:15572692).
Boster Bio offers antibodies to the anti–Abl interactor 2 marker (ABI2). Their high affinity primary antibodies are approved for Western Blot use. Boster biovalidates their antibodies across multiple platforms to further increase their affinity. Boster also offers product credits to first reviewers of new products, and rewards scientists around the world for their contributions to science.
Boster Bio Anti - Abl interactor2 ABI2 marker is a monoclonal, antibody that reacts against ABL2. ABL2 is used in many molecular biology applications. The protein plays an important role in cell growth, transformation, and cytoskeletal reorganization. ABI2 has been shown to play a part in phosphorylation MENA. It is a member from the ABL1/c–Abl group of proteins.
Researchers can use Boster Bio Anti Abl interactor2 Marker for a variety of biological processes. Boster Biologicals provides ELISA kit kits for the detection biomarkers in neurodevelopmental biology, cancer, inflammation, and neurosciences. This reagent can detect biomarkers as low as picograms. Boster Bio provides technical assistance to its customers for no charge.
The company's broad range of antibodies covers a wide range of applications, including ELISA, WB, immunohistochemistry, and more. These high-affinity antibodies are approved for use in WB and ELISA assays. Every product comes with a secondary antibody. Boster Bio products can be used in WB and ELISA applications. Each antibody has been rigorously validated. The company offers a 100% satisfaction warranty on all of its products.
The ABI2 marker from Boster and the high-affinity primary antibodies of Boster are particularly useful in neuroendocrine immunoassays. ABI2 is a marker that recognizes many immunoglobulins. This marker is used by researchers to identify cell types and target them with antibodies that can be tailored to each cell type. The company manufactures a wide variety of antibodies as well as ELISA kits in house, which guarantees their high quality.
Although high-affinity primaries antibodies are extremely useful in the detection and analysis of specific analytes (such as analytes), they are not always appropriate for other purposes. High affinity antibodies are more difficult to separate from non-bound materials than they are for specific analytes. Additionally, elution from the affinity columns may require more harsh methods. An ABI2 marker is ideal for ELISA as it allows researchers to detect and purify antigens that would otherwise remain undetectable in the sample.
High-affinity primary antibodies are highly sensitive, and their affinity increases as they are purified. They can be useful in detecting a wide range of proteins and antigens, which allows researchers the ability to identify the best targets for treatment. Secondary antibodies can be detected more quickly than primary antibodies. It does require additional incubation. This method is more sensitive than single antibody detection. However, optimization and cross reactivity management are essential for the technique.
Affinity Biologicals is another company that makes high-affinity antibodies. They offer the most comprehensive range of antibodies in hemostasis and supply diagnostic laboratories with antibodies and immune depleted plasmas. Agrisera offers plant biology researchers validated markers antibodies, Rubisco quantitation tool, and many other anti-inflammatory drugs.
Monoclonal anti-body products can also be produced by other companies in addition to ABI2 markers and high-affinity prim antibodies. The Goodwin Institute for Cancer Research, which is a leader in monoclonal antibodies, also offers anti-GFP anti-GFP clonal antibodies. They provide these antibodies using high-purity native Aequoria victoria GFP proteins. HyTest also offers antibody reagents to be used in research applications.
Boster Bio sets the standard for WB validation. Boster Bio has all the antibodies you need, from species to applications. All of their products are fully validated prior to being made available for sale. Boster scientists have the option to submit their results in species or applications for product credits. Boster validation can be used to benefit scientists all over the world. Sanbio is your contact for more information. Here are some benefits of Boster Validation.
Boster Bio also offers high affinity primary antibodies that have been Western Blot confirmed. These antibodies are well-respected by scientists and have been used in many research studies over the past 25 years. Boster also sells antibodies that have been validated via Immunohistochemistry/ELISA. These antibodies can also be used in your research with confidence. The best part is? Boster antibodies are covered by a full year's technical support.
Boster Bio is a manufacturer of high-quality antibodies, both for IHC and WB. Their lab has been working on their technology and techniques for over 25 years and has been awarded over 29,000 publications. The WB and ELISA antibody are optimized for multiple applications, including biology and neuroscience. They are also quantitatively validated, meaning that they work as described.
Moreover, Boster Bio validates all antibodies on WBL. This validates the quality of antibodies. Every antibody comes equipped with a full suite of validation tests. This allows scientists the ability to compare the results of different batches. This could improve reproducibility in the life sciences community around the world. The company also offers a wide range of other testing methods for their products. For more information, visit bosterbio.com.
Reproducibility requires a well-characterized reagent. The guidelines for antibody validation vary depending on the assay context. Because even small changes in the assay conditions could have an impact on the results, it's important to validate antibodies thoroughly to ensure reproducibility. Assay-specific validation ensures that primary antibodies perform in the assay. To ensure this, Boster Bio also validates all antibodies on WB.
PMID: 7590236 by Dai Z., et al. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.
PMID: 8649853 by Wang B., et al. Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.