- Table of Content
Chemokine binding doesn't trigger G-protein- mediated signal transduction but instead induces beta-arrestin recruitment, resulting in ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness.
|G-protein coupled receptor 1 family|
|Location:||1 D|1 45.28 cM|
Not detected in blood, liver, lung and heart, but high expression detected in several tumor cell lines (at protein level). Expressed in heart, spleen, kidney, lung, ovary, brain, testis, astrocytes, neutrophils and B-lymphocytes.
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