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- Table of Contents
ACOX1 Antibodies
AND ACOX1 ELISA kits, ACOX1 Proteins
Many biological assays use antibodies to detect ACOX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACOX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACOX1 antibodies...
Designing an IHC experiment for ACOX1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ACOX1 IHC GuideACOX1 Infographic by Boster Bio
All ACOX1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A03054-1
100 μg/vial
Cat # A03054-1
100 μg/vial
ACOX1 Overview
Facts about Peroxisomal acyl-coenzyme A oxidase 1.
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)
Catalyzes the desaturation of acyl-CoAs into 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.
Isoform 2 is active against a much broader range of substrates and reveals activity towards quite long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 from 16-hydroxy- palmitoyl-CoA and is 25% more active from 1,16-hexadecanodioyl- CoA.
Gene Information
| Human | |
|---|---|
| Gene Name: | ACOX1 |
| Uniprot: | Q15067 |
| Entrez: | 51 |
Family
| Belongs to: |
|---|
| acyl-CoA oxidase family |
Alternative Names
ACOXEC 1.3.3.6; acyl-CoA oxidase 1, palmitoyl; acyl-CoA oxidase, straight-chain; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; PALMCOX; Palmitoyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 1; peroxisomal fatty acyl-CoA oxidase; SCOXMGC1198; Straight-chain acyl-CoA oxidase
Molecular Weight
Mass (kDA):
74.424 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.1 |
| Sequence: | 17; NC_000017.11 (75941507..75979199, complement) |
Tissue Specificity
Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart.
Subcellular Localizations
Peroxisome.
Diseases
- Obesity
- Liver Carcinoma
- Steatohepatitis
- Carcinoma
- Malignant Neoplasms
- Peroxisomal Disorders
- Adrenoleukodystrophy
- Fatty Liver
- Steatosis
- Inflammation
- Liver Neoplasms
- Atherosclerosis
Pathways
- Fatty Acid Oxidation
- Secretion
- Transport
- Reverse Transcription
- Lipid Homeostasis
- Cell Proliferation
- Fatty Acid Beta-oxidation
- Lipid Oxidation
- Pathogenesis
- Glycolysis
- Tricarboxylic Acid Cycle
- Aging
- Gluconeogenesis
PTMs
- Oxidation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACOX1
bosterbio.com/bosterbio-gene-info-cards/ACOX1
References
PMID: 8159712 by Varanasi U., et al. Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization.
PMID: 7876265 by Chu R., et al. Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells.