Adhesion G-protein coupled receptor G1 (ADGRG1)

Receptor involved in cell adhesion and probably in cell- cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells.

Receptor for hydration III/COL3A1 in the developing brain and involved in regulation of embryonic growth, specifically in upkeep of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and potentially GNA12 (PubMed:22238662).