- Table of Contents
Over 100 substrate candidates have been reported so far, but for many of them, no isoform specificity was reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 sugar transporter to the cell surface.
|protein kinase superfamily|
|Sequence:||19; NC_000019.10 (40230317..40285531, complement)|
Expressed in all cell types so far analyzed.
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome. Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (By similarity).