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- Table of Contents
AKT2 Antibodies
AND AKT2 ELISA kits, AKT2 Proteins
Many biological assays use antibodies to detect AKT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKT2 antibodies...
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AKT2 Infographic by Boster Bio
All AKT2 Products
Product
Figures
Specificity
Applications
Price
Anti-AKT2 Antibody Picoband®
1 Citations 1 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9043
100 μg/vial
Cat # PB9043
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M00725-1
100 μg/vial
Cat # M00725-1
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1023
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1023
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2348
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2348
1 kit, containing two 96-well plates and all necessary reagents
AKT2 Overview
Facts about RAC-beta serine/threonine-protein kinase.
RAC-beta serine/threonine-protein kinase (AKT2)
AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates.
Over 100 substrate candidates have been reported so far, but for many of them, no isoform specificity was reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 sugar transporter to the cell surface.
Gene Information
| Human | |
|---|---|
| Gene Name: | AKT2 |
| Uniprot: | P31751 |
| Entrez: | 208 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Akt2; EC 2.7.11; EC 2.7.11.1; Murine thymoma viral (v-akt) homolog-2; PKB beta; PKBB; PKBBETA; PRKBB; Protein kinase Akt-2; Protein kinase B beta; rac protein kinase beta; RAC-beta serine/threonine-protein kinase; RAC-beta; RAC-PK-beta; v-akt murine thymoma viral oncogene homolog 2
Molecular Weight
Mass (kDA):
55.769 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (40230317..40285531, complement) |
Tissue Specificity
Expressed in all cell types so far analyzed.
Subcellular Localizations
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome. Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Insulin Resistance
- Carcinoma
- Cell Transformation, Neoplastic
- Diabetes Mellitus
- Malignant Neoplasm Of Breast
- Neoplasm Metastasis
- Ovarian Neoplasm
- Cell Invasion
- Mammary Neoplasms
- Malignant Neoplasm Of Ovary
- Obesity
Interacting Proteins
- GSK3B
- HSP90AB1
- VIM
Pathways
- Cell Proliferation
- Cell Growth
- Pathogenesis
- Transport
- Cell Migration
- Cell Cycle
- Cell Death
- Glucose Transport
- Localization
- Secretion
- Glucose Homeostasis
- Angiogenesis
- Rna Interference
PTMs
- Phosphorylation
- Dephosphorylation
- Oxidation
- Cleavage
- Methylation
- Myristoylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKT2
bosterbio.com/bosterbio-gene-info-cards/AKT2
References
PMID: 1801921 by Jones P.F., et al. Molecular cloning of a second form of rac protein kinase.
PMID: 1409633 by Cheng J.Q., et al. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
1 Publications of Boster AKT2 Antibodies & ELISA Kits
- PubMed ID: PMID:26550236, Vibration exercise decreases insulin resistance and modulates the insulin signal...
*More publications can be found for each product on its corresponding product page