Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Alkbh3)

Repairs alkylated DNA comprising 1-methyladenosine (m1A) and 3- methylcytosine (m3C) by oxidative demethylation (PubMed:16174769). Has a strong taste for single-stranded DNA (PubMed:16174769).

Willing to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to create single-stranded substrate needed for ALKBH3. Also acts on RNA.