Alkbh3 Antibodies

AND Alkbh3 ELISA kits, Alkbh3 Proteins

Many biological assays use antibodies to detect Alkbh3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alkbh3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alkbh3 antibodies...

We validate the specificity of these antibodies to Alkbh3 by testing them on tissues known to express Alkbh3 positively and negatively. Browse below to find the Alkbh3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Alkbh3 Infographic by Boster Bio

All Alkbh3 Products

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Product

Figures

Specificity

Applications

Price

Anti-ALKBH3 Antibody

WesternBlot (WB) analysis of ALKBH3 polyclonal antibody

Human, Mouse, Rat

$405
Cat # A06750
100ul

Human ALKBH3 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ96Q83
Starting from 20ug

ALKBH3 (NM_139178) Human Over-expression Lysate

Human

$628
Cat # LS221120
20 µg, 100 µg

Alkbh3 Overview

Facts about Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3.

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Alkbh3)

Repairs alkylated DNA comprising 1-methyladenosine (m1A) and 3- methylcytosine (m3C) by oxidative demethylation (PubMed:16174769). Has a strong taste for single-stranded DNA (PubMed:16174769).

Willing to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to create single-stranded substrate needed for ALKBH3. Also acts on RNA.

Gene Information

Mouse
Gene Name:	Alkbh3
Uniprot:	Q8K1E6
Entrez:	69113

Family

Belongs to:

alkB family

Alternative Names

ABH3MGC118793; alkB, alkylation repair homolog 3 (E. coli); Alkylated DNA repair protein alkB homolog 3; DEPC1alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC-1MGC118792; EC 1.14.11; EC 1.14.11.-; FLJ43614; MGC118790; PCA1; Prostate cancer antigen 1; prostate cancer antigen-1

Molecular Weight

Mass (kDA):
33.061 kDA

Genomic Context


Mouse

Location:	2\|2 E1
Sequence:	2;

Tissue Specificity

Detected in testis, kidney, liver and heart.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Carcinogenesis
Tumor Angiogenesis
Cell Invasion
Malignant Neoplasm Of Prostate
Genomic Instability
Carcinoma, Transitional Cell
Neurodegenerative Disorders
Glioma
Malignant Tumor Of Colon

Benign Prostatic Hypertrophy
Malignant Neoplasm Of Urinary Bladder
Malignant Neoplasm Of Lung
Pancreatitis
Pancreatic Neoplasm
Papillary Thyroid Carcinoma

Pathways

Demethylation
Dna Repair
Oxidative Demethylation
Cell Cycle
Methylation
Rna Repair
Gene Silencing
Cell Cycle Arrest
Translation
Cell Proliferation
Angiogenesis
Transport
Dna Alkylation

Dna Demethylation
Trna Methylation
Regulation Of Gene Expression
Rna Modification
G1 Phase
Dna Methylation
Senescence

PTMs

Demethylation
Methylation

Oxidation
Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Alkbh3

References

PMID: 16174769 by Lee D.-H., et al. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.

PMID: 16642038 by Ringvoll J., et al. Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.