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CNOT8 Antibodies
AND CNOT8 ELISA kits, CNOT8 Proteins
Many biological assays use antibodies to detect CNOT8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CNOT8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CNOT8 antibodies...
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CNOT8 Overview
Facts about CCR4-NOT transcription complex subunit 8.
CCR4-NOT transcription complex subunit 8 (CNOT8)
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function appears to be somewhat redundant with that of CNOT7.
Catalytic component of the CCR4-NOT complex that's linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and basic transcription regulation. During miRNA-mediated repression the complex appears also to act as translational repressor through translational initiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CNOT8 |
| Uniprot: | Q9UFF9 |
| Entrez: | 9337 |
Family
| Belongs to: |
|---|
| CAF1 family |
Alternative Names
CAF1; CAF2; CALIFCAF1-like protein; CALIFp; CCR4-NOT transcription complex subunit 8; CCR4-NOT transcription complex, subunit 8; hCAF1; PGK promoter directed over production; POP2CCR4-associated factor 8
Molecular Weight
Mass (kDA):
33.54 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.2 |
| Sequence: | 5; NC_000005.10 (154857952..154876792) |
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Inflammation
- Malignant Squamous Cell Neoplasm
- Tongue Neoplasms
- Malignant Neoplasm Of Tongue
- Neurodegenerative Disorders
- Malignant Neoplasm Of Breast
- Tissue Adhesions
- Sterility
- Carcinoma
Interacting Proteins
- BTG1
- BTG2
- CNOT1
- CNOT2
- CNOT3
- CNOT6
- CNOT6L
- TOB2
Pathways
- Cell Cycle
- Translation
- Cell Proliferation
- Chromatin Assembly
- Dna Repair
- Localization
- Nucleosome Assembly
- Oogenesis
- Senescence
- Methylation
- Regulation Of Cell Proliferation
- S Phase
- Cell Growth
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CNOT8
bosterbio.com/bosterbio-gene-info-cards/CNOT8
References
PMID: 10036195 by Fidler C., et al. The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome.
PMID: 10637334 by Albert T.K., et al. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.