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APH1A Antibodies
AND APH1A ELISA kits, APH1A Proteins
Many biological assays use antibodies to detect APH1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APH1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APH1A antibodies...
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APH1A Overview
Facts about Gamma-secretase subunit APH-1A.
Gamma-secretase subunit APH-1A (APH1A)
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335). Required for normal gamma- secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254).
The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). .
Gene Information
| Human | |
|---|---|
| Gene Name: | APH1A |
| Uniprot: | Q96BI3 |
| Entrez: | 51107 |
Family
| Belongs to: |
|---|
| APH-1 family |
Alternative Names
6530402N02Rik; anterior pharynx defective 1 homolog A (C. elegans); APH-1; APH1A; APH-1A; aph-1alpha; CGI-78; gamma-secretase subunit APH-1A; Presenilin-stabilization factor; PSF
Molecular Weight
Mass (kDA):
28.996 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.2 |
| Sequence: | 1; NC_000001.11 (150265399..150282179, complement) |
Tissue Specificity
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Diseases
- Alzheimer's Disease
- Plaque, Amyloid
- Alzheimer Disease, Familial
- Neurodegenerative Disorders
- Hypoxia
- Tumor Angiogenesis
- Tissue Adhesions
- Shwachman Syndrome
- Senile Plaques
- Sclerosis
- Primary Lateral Sclerosis
- Dementia
- Amyotrophic Lateral Sclerosis
Interacting Proteins
- NCSTN
Pathways
- Proteolysis
- Pathogenesis
- Localization
- Secretory Pathway
- Glycosylation
- Rna Interference
- Secretion
- Cell Death
- Angiogenesis
- Cell Adhesion
- Transport
- Aging
- Tissue Development
PTMs
- Cleavage
- Glycosylation
- Gamma-cleavage
- Palmitoylation
Research Areas
- GPCR
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APH1A
bosterbio.com/bosterbio-gene-info-cards/APH1A
References
PMID: 12297508 by Lee S.-F., et al. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
PMID: 12110170 by Francis R., et al. aph-1 and pen-2 are required for Notch pathway signaling, gamma- secretase cleavage of betaAPP, and presenilin protein accumulation.