Asporin Antibodies

AND ASPN ELISA kits, Asporin Proteins

Many biological assays use antibodies to detect Asporin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Asporin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Asporin antibodies...

We validate the specificity of these antibodies to Asporin by testing them on tissues known to express ASPN positively and negatively. Browse below to find the ASPN antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ASPN Infographic by Boster Bio

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ASPN Overview

Facts about Asporin.

ASPN 3D structure. Source: alphafold

Asporin (ASPN)

Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, leading to inhibition of BMP-dependent activation of SMAD proteins (By similarity).

Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF- beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal.

Gene Information

Human
Gene Name:	ASPN
Uniprot:	Q9BXN1
Entrez:	54829

Family

Belongs to:

small leucine-rich proteoglycan (SLRP) family

Alternative Names

asporin (LRR class 1); asporin; FLJ20129; OS3; periodontal ligament associated protein 1; Periodontal ligament-associated protein 1; PLAP-1; PLAP1SLRR1Casporin proteoglycan; small leucine-rich protein 1C

Molecular Weight

Mass (kDA):
43.417 kDA

Genomic Context


Human

Location:	9q22.31
Sequence:	9; NC_000009.12 (92456205..92482506, complement)

Tissue Specificity

Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Colocalizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Degenerative Polyarthritis
Osteoarthritis, Knee
Neoplasms
Carcinoma
Malignant Neoplasms
Arthritis
Arthropathy
Osteoarthritis Of Hip
Headache
Hemorrhage
Ear Inflammation
Otitis Media
Osteophyte

Carcinoma In Situ
Pain
Mammary Neoplasms
Depressive Disorder
Brain Neoplasms
Intracranial Neoplasm
Neoplasms, Germ Cell And Embryonal

Pathways

Pathogenesis
Aging
Localization
Osteoblast Differentiation
Wound Healing
Dedifferentiation
Striated Muscle Contraction
Fibril Organization
Muscle Contraction
Chondrocyte Differentiation
Spermatogenesis
Cell Maturation
Cell Cycle

Cell Motility
Collagen Fibril Organization
Bone Development
Cell Communication
Cell Development
Germ Cell Development
Hatching

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASPN

References

PMID: 11152692 by Lorenzo P., et al. Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan.

PMID: 11587855 by Yamada S., et al. Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene.