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- Table of Contents
ATF6 Antibodies
AND ATF6 ELISA kits, ATF6 Proteins
Many biological assays use antibodies to detect ATF6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATF6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATF6 antibodies...
Designing a Western blot for ATF6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ATF6 Western Blot GuideATF6 Infographic by Boster Bio
All ATF6 Products
Product
Figures
Specificity
Applications
Price
Anti-ATF6 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00655-3
100 μg/vial
Cat # A00655-3
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00655-4
100 μg/vial
Cat # A00655-4
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, WB
$146
Cat # M00655-1
20μL, 40μL, 100μL, 200μL
Cat # M00655-1
20μL, 40μL, 100μL, 200μL
Functional Assay
$2072
Cat # RC1038
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO.
Cat # RC1038
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO.
ATF6 Overview
Facts about Cyclic AMP-dependent transcription factor ATF-6 alpha.
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)
Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates into the nucleus where it activates transcription of genes involved in the UPR.
Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'- ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATF6 |
| Uniprot: | P18850 |
| Entrez: | 22926 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
ACHM7; Activating transcription factor 6 alpha; activating transcription factor 6; atf6 a; ATF6 alpha; ATF6; ATF6A; ATF6-alpha; cAMP-dependent transcription factor ATF-6 alpha; cyclic AMP-dependent transcription factor ATF-6 alpha
Molecular Weight
Mass (kDA):
74.585 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (161766320..161964070) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.
Diseases
- Endoplasmic Reticulum Stress
- Physiological Stress
- Malignant Neoplasms
- Diabetes Mellitus
- Neoplasms
- Inflammation
- Neurodegenerative Disorders
- Diabetes Mellitus, Non-insulin-dependent
- Ischemia
- Carcinoma
- Hypoxia
- Obesity
Interacting Proteins
- CREB3L3
- CRTC2
- Crtc2
- HSPA5
- XBP1
Pathways
- Cell Death
- Translation
- Protein Folding
- Proteolysis
- Pathogenesis
- Secretion
- Transport
- Localization
- Glycosylation
- Secretory Pathway
- Cell Growth
- Autophagy
- Mrna Splicing
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Glycosylation
- Reduction
- Methylation
Research Areas
- Lipid and Metabolism
- Signal Transduction
- Unfolded Protein Response
- Unfolded Protein Response (UPR)
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATF6
bosterbio.com/bosterbio-gene-info-cards/ATF6
References
PMID: 9271374 by Zhu C., et al. Interaction of ATF6 and serum response factor.
PMID: 9837962 by Yoshida H., et al. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors.
1 Publications of Boster ATF6 Antibodies & ELISA Kits
- PubMed ID: 10.3390/jcm10112529, GSH-Independent Induction of ER Stress during Hypoglycaemia in the Retinal Cells...
*More publications can be found for each product on its corresponding product page