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- Table of Contents
Cysteine protease ATG4D Antibodies
AND ATG4D ELISA kits, Cysteine protease ATG4D Proteins
Many biological assays use antibodies to detect Cysteine protease ATG4D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cysteine protease ATG4D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cysteine protease ATG4D antibodies...
Designing an IHC experiment for Cysteine protease ATG4D? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ATG4D IHC GuideATG4D Infographic by Boster Bio
All ATG4D Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A09793
0.1 mg
Cat # A09793
0.1 mg
ATG4D Overview
Facts about Cysteine protease ATG4D.
Cysteine protease ATG4D (ATG4D)
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine.
Exposure of the glycine in the C-terminus is vital for ATG8 proteins conjugation into phosphatidylethanolamine (PE) and insertion to membranes, which is essential for autophagy. Has also an activity of delipidating receptor to the PE-conjugated forms.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATG4D |
| Uniprot: | Q86TL0 |
| Entrez: | 84971 |
Family
| Belongs to: |
|---|
| peptidase C54 family |
Alternative Names
APG4 autophagy 4 homolog D (S. cerevisiae); APG4 autophagy 4 homolog D; APG4D; APG4-D; ATG4 autophagy related 4 homolog D (S. cerevisiae); AUTL4; AUT-like 4 cysteine endopeptidase; AUT-like 4, cysteine endopeptidase (S. cerevisiae); AUT-like 4, cysteine endopeptidase; autophagin-4; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D; cysteine protease ATG4D; cysteine protease involved in autophagy; EC 3.4.22; EC 3.4.22.-
Molecular Weight
Mass (kDA):
52.922 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (10543897..10553418) |
Tissue Specificity
Mainly expressed in skeletal muscle and, to a lower extent, in testis.
Subcellular Localizations
[Cysteine protease ATG4D]: Cytoplasm.; [Cysteine protease ATG4D, mitochondrial]: Cytoplasm. Mitochondrion matrix. Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death.
Diseases
- Granuloma
- Infective Disorder
- Virus Diseases
- Malignant Neoplasms
- Neoplasms
- Hiv Infections
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
Pathways
- Autophagy
- Cell Death
- Catabolic Process
- Pathogenesis
- Viral Replication
- Granuloma Formation
PTMs
Research Areas
- Autophagy
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATG4D
bosterbio.com/bosterbio-gene-info-cards/ATG4D
References
PMID: 12446702 by Marino G., et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.
PMID: 19549685 by Betin V.M., et al. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.