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ATP2A1 Antibodies
AND ATP2A1 ELISA kits, ATP2A1 Proteins
Many biological assays use antibodies to detect ATP2A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP2A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP2A1 antibodies...
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ATP2A1 Infographic by Boster Bio
All ATP2A1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1719
100 μg/vial
Cat # PA1719
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # RP1053
100 μg/vial
Cat # RP1053
100 μg/vial
Anti-SERCA2 ATPase/ATP2A2 Antibody Picoband®
2 Citations
Mouse, Rat
IHC, WB
$370
Cat # RP1054
100 μg/vial
Cat # RP1054
100 μg/vial
ATP2A1 Overview
Facts about Sarcoplasmic/endoplasmic reticulum calcium ATPase 1.
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1)
Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen.
Contributes to calcium sequestration involved in muscle excitation/contraction. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ATP2A1 |
| Uniprot: | O14983 |
| Entrez: | 487 |
Family
| Belongs to: |
|---|
| cation transport ATPase (P-type) (TC 3.A.3) family |
Alternative Names
ATP2A; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletalmuscle isoform; EC 3.6.3; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1EC 3.6.3.8; SR Ca(2+)-ATPase 1
Molecular Weight
Mass (kDA):
110.252 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p11.2 |
| Sequence: | 16; NC_000016.10 (28878488..28904511) |
Tissue Specificity
Skeletal muscle, fast twitch muscle (type II) fibers.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Endometriosis, Site Unspecified
- Myopathy
- Observation Of Neuromuscular Block
- Dystrophy
- Muscle Twitch
- Heart Failure
- Diabetes Mellitus
- Myotonic Dystrophy
- Disorder Of Skeletal Muscle
- Diabetes Mellitus, Non-insulin-dependent
- Malignant Neoplasms
- Keratosis Follicularis
Pathways
- Transport
- Localization
- Aging
- Muscle Contraction
- Sensitization
- Innervation
- Pathogenesis
- Relaxation Of Vascular Smooth Muscle
- Gene Silencing
- Immune Response
- Swimming Behavior
- Flight
- Mrna Splicing
PTMs
- Oxidation
- Phosphorylation
- Nitration
- Nitrosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP2A1
bosterbio.com/bosterbio-gene-info-cards/ATP2A1
References
PMID: 8825625 by Zhang Y., et al. Characterization of cDNA and genomic DNA encoding SERCA1, the Ca(2+)- ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease.
PMID: 10914677 by Odermatt A., et al. The mutation of Pro(789) to Leu reduces the activity of the fast- twitch skeletal muscle sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA1) and is associated with Brody disease.
1 Publications of Boster ATP2A1 Antibodies & ELISA Kits
- PubMed ID: 24324360, Guo Y, Zeng Qc, Zhang Cq, Zhang Xz, Li Rx, Wu Jm, Guan J, Liu L, Zhang Xc, Li Jy...
*More publications can be found for each product on its corresponding product page