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- Table of Contents
ATRX Antibodies
AND ATRX ELISA kits, ATRX Proteins
Many biological assays use antibodies to detect ATRX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATRX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATRX antibodies...
Designing a Western blot for ATRX? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ATRX Western Blot GuideATRX Infographic by Boster Bio
All ATRX Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$540
Cat # EKC2026
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2026
1 kit, containing two 96-well plates and all necessary reagents
ATRX Overview
Facts about Transcriptional regulator ATRX.
Transcriptional regulator ATRX (ATRX)
Facilitates DNA replication in multiple mobile environments and is necessary for efficient replication of a subset of genomic loci. May help stabilizing G-rich regions into routine chromatin structures by remodeling G4 DNA and integrating H3.
3- containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX that has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.
Gene Information
| Human | |
|---|---|
| Gene Name: | ATRX |
| Uniprot: | P46100 |
| Entrez: | 546 |
Family
| Belongs to: |
|---|
| SNF2/RAD54 helicase family |
Alternative Names
alpha thalassemia/mental retardation syndrome X-linked (RAD54 (S. cerevisiae)homolog); alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S.cerevisiae); alpha thalassemia/mental retardation syndrome X-linked; ATP-dependent helicase ATRX; ATR2; DNA dependent ATPase and helicase; EC 3.6.1; EC 3.6.4.12; helicase 2, X-linked; Juberg-Marsidi syndrome; MGC2094; MRXHF1; RAD54 homolog; RAD54L; SFM1; SHS; transcriptional regulator ATRX; XH2RAD54; X-linked helicase II; X-linked nuclear protein; XNPZNF-HX; Zinc finger helicase; Znf-HX
Molecular Weight
Mass (kDA):
282.586 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq21.1 |
| Sequence: | X; NC_000023.11 (77504878..77786235, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Chromosome, telomere. Nucleus, PML body. Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML-nuclear bodies. Colocalizes with cohesin (SMC1 and SMC3) and MECP2 at the maternal H19 ICR (By similarity).
Diseases
- Alpha-thalassemia
- Alpha-thalassemia/mental Retardation Syndrome, Nondeletion Type, X-linked
- Thalassemia
- Neoplasms
- Leukemia
- Severe Mental Retardation
- Malignant Neoplasms
- Dysmyelopoietic Syndromes
- Acute Promyelocytic Leukemia
- Congenital Anomaly Of Face
Interacting Proteins
- CBX5
- DAXX
- EZH2
- Mecp2
- RAD50
Pathways
- Chromatin Remodeling
- Methylation
- Localization
- Dna Methylation
- Pathogenesis
- Mitosis
- Cell Cycle
- Meiosis
- Brain Development
- Metaphase
- Sex Determination
- Atp-dependent Chromatin Remodeling
- Sex Differentiation
PTMs
- Methylation
- Phosphorylation
- Sumoylation
Research Areas
- Cancer
- Checkpoint signaling
- DNA Double Strand Break Repair
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATRX
bosterbio.com/bosterbio-gene-info-cards/ATRX
References
PMID: 8968741 by Picketts D.J., et al. ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome.
PMID: 9244431 by Villard L., et al. Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase.
1 Publications of Boster ATRX Antibodies & ELISA Kits
- PubMed ID: -, Co-occurrence of ATRX and IDH Mutations Identify Subgroup of Glioma Patients for...
*More publications can be found for each product on its corresponding product page