B-cell lymphoma 6 protein (BCL6)

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation that has different mechanisms of action specific to the lineage and biological purposes. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes.

In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of several genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, such as miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without causing a p53/TP53-dependent apoptotic response.