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B-cell lymphoma 6 protein Antibodies
AND BCL6 ELISA kits, B-cell lymphoma 6 protein Proteins
Many biological assays use antibodies to detect B-cell lymphoma 6 protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with B-cell lymphoma 6 protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop B-cell lymphoma 6 protein antibodies...
Designing a Western blot for B-cell lymphoma 6 protein? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BCL6 Western Blot GuideBCL6 Infographic by Boster Bio
All BCL6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1056
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1056
1 kit, containing one 96-well plate and all necessary reagents
BCL6 Overview
Facts about B-cell lymphoma 6 protein.
B-cell lymphoma 6 protein (BCL6)
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation that has different mechanisms of action specific to the lineage and biological purposes. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes.
In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of several genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, such as miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without causing a p53/TP53-dependent apoptotic response.
Gene Information
| Human | |
|---|---|
| Gene Name: | BCL6 |
| Uniprot: | P41182 |
| Entrez: | 604 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
B-cell CLL/lymphoma 6; B-cell lymphoma 6 protein transcript; Bcl-5; BCL5B-cell lymphoma 5 protein; Bcl6; Bcl-6; BCL6A; cys-his2 zinc finger transcription factor; LAZ3; LAZ3ZBTB27B-cell lymphoma 6 protein; lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; ZBTB27 ; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51ZNF51; zinc finger transcription factor BCL6S; ZNF51
Molecular Weight
Mass (kDA):
78.846 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q27.3 |
| Sequence: | 3; NC_000003.12 (187721377..187745472, complement) |
Tissue Specificity
Expressed in germinal center T- and B-cells and in primary immature dendritic cells.
Subcellular Localizations
Nucleus.
Diseases
- Lymphoma
- B-cell Lymphomas
- Diffuse Large B-cell Lymphoma
- Neoplasms
- Chromosomal Translocation
- Lymphoma, Follicular
- Lymphoma, Non-hodgkin
- Malignant Neoplasms
- Leukemogenesis
- Burkitt Lymphoma
- Cytogenetic Abnormality
- Malignant Paraganglionic Neoplasm
- Leukemia
Interacting Proteins
- AES
- BLZF1
- Crebbp
- CUTC
- FBXO11
- GOLGA2
- HDAC4
- HDAC9
- KIFC3
- LIMS4
Pathways
- Pathogenesis
- Cell Differentiation
- Interphase
- Cell Cycle
- Cell Development
- Cell Proliferation
- Plasma Cell Differentiation
- Immune Response
- Germinal Center Formation
- B Cell Differentiation
- Localization
- Cell Growth
- Methylation
PTMs
- Methylation
- Phosphorylation
- Acetylation
- Deacetylation
- Cleavage
- Demethylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCL6
bosterbio.com/bosterbio-gene-info-cards/BCL6
References
PMID: 8220427 by Kerckaert J.-P., et al. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.
PMID: 8235596 by Ye B.H., et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large- cell lymphoma.
1 Publications of Boster B-cell lymphoma 6 protein Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.molimm.2020.06.003, An imbalance between blood CD4+CXCR5+Foxp3+ Tfr cells and CD4+CXCR5+Tfh cells ma...
*More publications can be found for each product on its corresponding product page