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- Table of Contents
10 Q&As
10 Q&As
1 Citations
Facts about Early activation antigen CD69.
Human | |
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Gene Name: | CD69 |
Uniprot: | Q07108 |
Entrez: | 969 |
Belongs to: |
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No superfamily |
activation inducer molecule (AIM/CD69); Activation inducer molecule; AIM; BL-AC/P26; CD69 antigen (p60, early T-cell activation antigen); CD69 antigen; CD69 molecule; CD69; CLEC2CC-type lectin domain family 2 member C; C-type lectin domain family 2, member C; EA1; EA-1; early activation antigen CD69; early lymphocyte activation antigen; Early T-cell activation antigen p60; GP32/28; Leu23; Leukocyte surface antigen Leu-23; MLR-3; p60
Mass (kDA):
22.559 kDA
Human | |
---|---|
Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (9752486..9760901, complement) |
Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.
Membrane; Single-pass type II membrane protein.
The CD69 marker is a biomarker, which can be found on early activation antigen. This marker can be utilized by scientists to analyze samples from various species and applications. Boster scientists can submit their findings for credit on the product and special samples. Boster Bio has products for scientists worldwide. Here are some examples of Boster Bio products:
You've come to the right spot if you're looking for an antibody that detects early activation of CD69 protein. The Boster Bio Anti-Early Activation Antigen CD69 Antibody (Catalog No. An ELISA kit that has been tested against mouse, human, and the rat's tissues (Catalog No. A00529). It has been validated using WB and ELISA against known quantities of recombinant protein.
The protein that CD69 recognizes is activated by T lymphocyte activation. It can act as a signal transducer to natural killer cells and platelets. It may also play a role in the process of proliferation. It is not clear how CD69 is involved in any way to disease processes. Although the antigen does not function as an antigen specific to T lymphocytes, it is a component of many immune system-related disorders.
CD69 is an a-type II C-lectin receptor that is expressed by lymphocytes. It regulates the expression of many other antigens, such as growth factors and cytokines. Additionally to that, it is found on the plasma membrane of various subsets of immune cells that reside in the tissue, such as memory T cells as well as gamma delta T lymphocytes. CD69 is also important for the retention of tissue, since it regulates the proportion between migration and retention. It also helps in the differentiation of regulatory T cells. It is also essential for the secretion IL-17 and IL-22.
It is believed that CD69 binds to Gal-1 on DCs which boosts the production of IL-10 by T cell. CD69 interacts with protein residues as well as carbohydrate residues and can regulate the immune system. Gal-1, a specific ligand for CD69 has been demonstrated. The phenotypes in mice with CD69 deficiency are enhanced by the absence Gal-1.
Although the inflammatory response stimulated by CD69 is negative in the majority of instances, the positive regulatory role of CD69 in the immune response is not apparent. Further research is likely to examine the role of CD69 in different immune cell types and in different contexts. It is believed that the CD69 protein regulates the activity of neutrophils in certain conditions of inflammation.
The antigen-capturing B cells produce distinct markers from the global B cell population. This makes them able to be detected without the use of a fluorescent antigen marker. The enrichment ratio in post-vaccination samples was around 100 times, whereas the enrichment rate was about tenfold for steady state samples. This indicates that CD69-expressing cell can be used to produce antibodies that are specific to specific antigens.
Boster Bio Anti Bax (Bax), Antibody uses the CD69 marker to detect Bax in Human cells. Boster scientists may submit their results to Boster for specific species-specific applications, samples and credits. This product is accessible to all scientists in the world. It interacts with the CD69 marker which is found on Human and E. Coli cells.
The TCA Kit from Boster Bio measures the activation of T-cells, cell growth, viability, and secreted cytokines. This plate format, which is available in 384-well or 96-well versions can be used to perform various functional tests, including the development or modification of therapies for cells and checkpoint inhibitors. This kit can also be utilized in the process of manufacturing cells.
The TCA Kit requires 10 microliters of sample. After the sample is taken, it is required to be examined. Data acquisition can be completed in less than four hours. The Boster Bio Anti-Early Activation Antibody also reacts with Rat, Mouse, and Human. The kit is compatible for different types of cells and has seven-decades of dynamic range. It can therefore distinguish between different types of cells.
PMID: 8496594 by Hamann J., et al. Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain.
PMID: 8340758 by Lopez-Cabrera M., et al. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.
*More publications can be found for each product on its corresponding product page