CIRBP Antibodies

AND CIRBP ELISA kits, CIRBP Proteins

Many biological assays use antibodies to detect CIRBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CIRBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CIRBP antibodies...

We validate the specificity of these antibodies to CIRBP by testing them on tissues known to express CIRBP positively and negatively. Browse below to find the CIRBP antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CIRBP Infographic by Boster Bio

All CIRBP Products

Product

Figures

Specificity

Applications

Price

Anti-CIRBP Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A04103
100ul

Human CIRBP Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ14011
Starting from 20ug

Anti-CIRBP Rabbit Monoclonal Antibody

1 Citations

Human

IP, IF, IHC, ICC, WB

$370
Cat # M04103
100 μl/vial

CIRBP (NM_001280) Human Over-expression Lysate

Human

$628
Cat # LS001153
100 µg

CIRBP Overview

Facts about Cold-inducible RNA-binding protein.

CIRBP 3D structure. Source: alphafold

Cold-inducible RNA-binding protein (CIRBP)

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator.

Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN.

Gene Information

Human
Gene Name:	CIRBP
Uniprot:	Q14011
Entrez:	1153

Family

Belongs to:

No superfamily

Alternative Names

A18 hnRNP; A18HNRNP; CIRPcold-inducible RNA-binding protein; cold inducible RNA binding protein; cold inducible RNA-binding protein; glycine-rich RNA binding protein; Glycine-rich RNA-binding protein CIRP

Molecular Weight

Mass (kDA):
18.648 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (1269268..1274880)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus, nucleoplasm. Cytoplasm. Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).

Diseases

Malignant Neoplasms
Hypoxia
Brain Injuries
Infertility
Neoplasms
Growth Arrest
Growth Retardation
Brain Ischemia
Carcinoma
Ischemia
Physiological Stress
Male Infertility

Cryptorchidism
Burkitt Lymphoma
Malignant Neoplasm Of Breast
Neoplasm Invasiveness
Carcinoma In Situ
Acute-phase Reaction
Azoospermia

Interacting Proteins

HNRNPK
KHDRBS2
LNX1
RBMX
RBMY1A1

RBMY1F
SNRPA

Pathways

Cell Growth
Translation
Spermatogenesis
Cell Cycle
Cell Proliferation
Immune Response
G1 Phase
Localization
Senescence
Methylation
Transport
Response To Lipopolysaccharide
Interferon-gamma Production

Sex Determination
Inflammatory Response
Replicative Senescence
Mrna Stabilization
Response To Stress
Circadian Rhythm
Response To Stimulus

PTMs

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CIRBP

References

PMID: 9434172 by Nishiyama H., et al. Cloning and characterization of human CIRP (cold-inducible RNA- binding protein) cDNA and chromosomal assignment of the gene.

PMID: 9334257 by Sheikh M.S., et al. Identification of several human homologs of hamster DNA damage- inducible transcripts. Cloning and characterization of a novel UV- inducible cDNA that codes for a putative RNA-binding protein.

1 Publications of Boster CIRBP Antibodies & ELISA Kits

PubMed ID: 10.1093/icvts/ivx262, Cold-inducible ribonucleic acid-binding protein attenuates acute kidney injuries...

*More publications can be found for each product on its corresponding product page