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COL8A1 Antibodies
AND COL8A1 ELISA kits, COL8A1 Proteins
Many biological assays use antibodies to detect COL8A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COL8A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COL8A1 antibodies...
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COL8A1 Overview
Facts about Collagen alpha-1(VIII) chain.
Collagen alpha-1(VIII) chain (COL8A1)
Macromolecular part of the subendothelium. Major part of the Descemet's membrane (basement membrane) of corneal endothelial cells.
Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | COL8A1 |
| Uniprot: | P27658 |
| Entrez: | 1295 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
alpha-1 polypeptide; chromosome 3 open reading frame 7; collagen, type VIII, alpha 1; smooth muscle cell-expressed and macrophage conditioned medium-induced proteinsmag-64
Molecular Weight
Mass (kDA):
73.364 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q12.1 |
| Sequence: | 3; NC_000003.12 (99638594..99799217) |
Tissue Specificity
Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix, basement membrane.
Diseases
- Diabetic Nephropathy
- Fuchs Endothelial Dystrophy
- Dystrophy
- Kidney Diseases
- Fibrosis
- Neoplasms
- Congenital Abnormality
- Liver Carcinoma
- Diabetes Mellitus
- Diabetes Mellitus, Experimental
- Liver Neoplasms
- Glomerulosclerosis (disorder)
Interacting Proteins
- CYSRT1
- HOXA1
- INCA1
- KLHL12
- KRT40
- KRTAP10-7
- KRTAP10-8
- KRTAP26-1
- KRTAP9-2
- NOTCH2NL
Pathways
- Pathogenesis
- Cell Adhesion
- Cell Migration
- Cell Proliferation
- Notochord Morphogenesis
- Muscle Cell Migration
- Smooth Muscle Cell Migration
- Mastication
- Metaphase
- Flight
- Tissue Development
- Basement Membrane Assembly
- Cell Cycle
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COL8A1
bosterbio.com/bosterbio-gene-info-cards/COL8A1
References
PMID: 2029894 by Muragaki Y., et al. The complete primary structure of the human alpha 1 (VIII) chain and assignment of its gene (COL8A1) to chromosome 3.
PMID: 2376131 by Kittelberger R., et al. Distribution of type VIII collagen in tissues: an immunohistochemical study.