COL8A2 Antibodies

AND COL8A2 ELISA kits, COL8A2 Proteins

Many biological assays use antibodies to detect COL8A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COL8A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COL8A2 antibodies...

We validate the specificity of these antibodies to COL8A2 by testing them on tissues known to express COL8A2 positively and negatively. Browse below to find the COL8A2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COL8A2 Infographic by Boster Bio

All COL8A2 Products

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Specificity

Applications

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Anti-Collagen alpha-2(VIII) chain COL8A2 Antibody

Western Blot analysis of 1, hela 2, 3T3 cells using primary antibody diluted at 1:500 (4°C overnight)

Human, Mouse, Rat

ELISA, WB

$380
Cat # A05649
100ul

COL8A2 (NM_005202) Human Recombinant Protein

Coomassie blue staining of purified COL8A2 protein

$1249
Cat # PROTP25067
20 µg

COL8A2 (NM_005202) Human Over-expression Lysate

Human

$960
Cat # LS001296
20 µg, 100 µg

COL8A2 Overview

Facts about Collagen alpha-2(VIII) chain.

COL8A2 3D structure. Source: alphafold

Collagen alpha-2(VIII) chain (COL8A2)

Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells.

Additionally component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and so, has a potential role in the maintenance of vessel wall integrity and construction, in particular in atherogenesis (By similarity).

Gene Information

Human
Gene Name:	COL8A2
Uniprot:	P25067
Entrez:	1296

Family

Belongs to:

No superfamily

Alternative Names

alpha-2 polypeptide; collagen, type VIII, alpha 2; dJ665N4.1 (collagen type VIII alpha 2); FECD; FLJ00201; MGC116970; PPCD; PPCD2MGC116972

Molecular Weight

Mass (kDA):
67.244 kDA

Genomic Context


Human

Location:	1p34.3
Sequence:	1; NC_000001.11 (36095239..36126207, complement)

Tissue Specificity

Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix, basement membrane.

Diseases

Dystrophy
Corneal Diseases
Fuchs Endothelial Dystrophy
Hereditary Corneal Dystrophy
Chandler Syndrome
Polymorphous Corneal Dystrophy
Glaucoma
Edema
Diabetic Nephropathy
Corneal Dystrophy, Fuchs' Endothelial, 1
Blind Vision
Kidney Diseases

Corneal Edema
Congenital Keratoglobus
Eye Abnormalities
Tissue Adhesions
Disorder Of Eye
Ehlers-danlos Syndrome 6b

Pathways

Pathogenesis
Cell Proliferation
Aging
Cell Adhesion
Localization
Senescence
Basement Membrane Assembly
Translation
Cell Cycle

Cell Death
Membrane Assembly
Eye Development
Secretion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COL8A2

References

PMID: 2019595 by Muragaki Y., et al. The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1.

PMID: 1515454 by Kittelberger R., et al. Cleavage of type VIII collagen by human neutrophil elastase.