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Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficacy. Doesn't hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules more than 25 nucleotides.
|Sequence:||11; NC_000011.10 (126304060..126350005)|
Detected in liver, brain, kidney, testis and prostate.
Cytoplasm. Nucleus. Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.