DENND1B Antibodies

AND DENND1B ELISA kits, DENND1B Proteins

Many biological assays use antibodies to detect DENND1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DENND1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DENND1B antibodies...

We validate the specificity of these antibodies to DENND1B by testing them on tissues known to express DENND1B positively and negatively. Browse below to find the DENND1B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DENND1B Infographic by Boster Bio

All DENND1B Products

Product

Figures

Specificity

Applications

Price

DENND1B (NM_144977) Human Over-expression Lysate

Human

$628
Cat # LS163486
100 µg

DENND1B Overview

Facts about DENN domain-containing protein 1B.

DENND1B 3D structure. Source: alphafold

DENN domain-containing protein 1B (DENND1B)

Guanine nucleotide exchange factor (GEF) for RAB35 that serves as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by encouraging the exchange of GDP to GTP, converting inactive GDP-bound RAB35 to its busy GTP-bound form (PubMed:20154091, PubMed:20937701).

Plays a role in clathrin- mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the speed of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR through its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822).

Gene Information

Human
Gene Name:	DENND1B
Uniprot:	Q6P3S1
Entrez:	163486

Family

Belongs to:

No superfamily

Alternative Names

C1ORF18; C1orf218; chromosome 1 open reading frame 218; Connecdenn 2; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; DKFZp547O0715; FAM31BMGC103810; FLJ20054; FLJ21179; FLJ33888; member B; Protein FAM31B

Molecular Weight

Mass (kDA):
86.552 kDA

Genomic Context


Human

Location:	1q31.3
Sequence:	1; NC_000001.11 (197504748..197782138, complement)

Tissue Specificity

Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T- cells as compared with naive T-cells.