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- Table of Contents
Facts about DENN domain-containing protein 1B.
Plays a role in clathrin- mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the speed of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR through its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822).
Human | |
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Gene Name: | DENND1B |
Uniprot: | Q6P3S1 |
Entrez: | 163486 |
Belongs to: |
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No superfamily |
C1ORF18; C1orf218; chromosome 1 open reading frame 218; Connecdenn 2; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; DKFZp547O0715; FAM31BMGC103810; FLJ20054; FLJ21179; FLJ33888; member B; Protein FAM31B
Mass (kDA):
86.552 kDA
Human | |
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Location: | 1q31.3 |
Sequence: | 1; NC_000001.11 (197504748..197782138, complement) |
Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T- cells as compared with naive T-cells.
Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle.
PMID: 20154091 by Marat A.L., et al. The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.
PMID: 20937701 by Yoshimura S., et al. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.