Protein Dr1 Antibodies

AND DR1 ELISA kits, Protein Dr1 Proteins

Many biological assays use antibodies to detect Protein Dr1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein Dr1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein Dr1 antibodies...

We validate the specificity of these antibodies to Protein Dr1 by testing them on tissues known to express DR1 positively and negatively. Browse below to find the DR1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DR1 Infographic by Boster Bio

All DR1 Products

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Product

Figures

Specificity

Applications

Price

Anti-Protein Dr1 DR1 Antibody

Western blot analysis of Mouse testis, using DR1 antibody at 1:720 dilution

Human, Mouse, Rat

$405
Cat # A02204
100ul

Anti-DR1 Antibody Picoband®

Western blot analysis of DR1 using anti-DR1 antibody (A02204-1)

IHC analysis of DR1 using anti-DR1 antibody (A02204-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02204-1
100 μg/vial

DR1 (NM_001938) Human Recombinant Protein

Coomassie blue staining of purified DR1 protein

$1249
Cat # PROTQ01658
20 µg

DR1 (NM_001938) Human Over-expression Lysate

Human

$628
Cat # LS001810
20 µg, 100 µg

DR1 Overview

Facts about Protein Dr1.

DR1 3D structure. Source: alphafold

Protein Dr1 (DR1)

The institution of this DR1/DRAP1 heterodimer with TBP leads to a functional repression of both activated and basal transcription of class II genes. This interaction precludes the creation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP.

Can bind to DNA by itself. Part of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Information

Human
Gene Name:	DR1
Uniprot:	Q01658
Entrez:	1810

Family

Belongs to:

NC2 beta/DR1 family

Alternative Names

Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); NC2; NC2-BETA; Negative cofactor 2-beta; protein Dr1; TATA-binding protein-associated phosphoprotein

Molecular Weight

Mass (kDA):
19.444 kDA

Genomic Context


Human

Location:	1p22.1
Sequence:	1; NC_000001.11 (93345907..93369493)

Subcellular Localizations

Nucleus.

Diseases

Arthritis
Rheumatoid Arthritis
Hepatitis
Hepatitis B
Dysequilibrium Syndrome
Influenza
Diabetes Mellitus
Autoimmune Reaction
Diabetes Mellitus, Insulin-dependent
Autoimmune Diseases
Carcinoma
Neoplasms

Malignant Neoplasms
Liver Carcinoma
Congenital Adrenal Hyperplasia
Sclerosis
Headache
Autoimmunity
Inflammation

Interacting Proteins

DRAP1
POLE3

Pathways

Immune Response
Pathogenesis
Reverse Transcription
Cell Recognition
Cell Activation
Sensitization
Secretion
T Cell Activation
Cell Proliferation
Localization
Gene Conversion
Translation
Transport

T Cell Proliferation
Dna Replication
Cell Death
Hypersensitivity
Biofilm Formation
Viral Replication
Proteolysis

PTMs

Cleavage
Phosphorylation
Biotinylation
Glycosylation
Methylation
Oxidation

Demethylation
Phosphorothioation
Deamination
Citrullination
Gpi Anchoring
Nitration

Deacetylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DR1

References

PMID: 1339312 by Inostroza J.A., et al. Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription.

PMID: 8670811 by Goppelt A.R., et al. A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains.