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- Table of Contents
DVL2 Antibodies
AND DVL2 ELISA kits, DVL2 Proteins
Many biological assays use antibodies to detect DVL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DVL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DVL2 antibodies...
Designing a Western blot for DVL2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DVL2 Western Blot GuideDVL2 Infographic by Boster Bio
All DVL2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02404-4
100 μg/vial
Cat # A02404-4
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M02404
100 µl
Cat # M02404
100 µl
DVL2 Overview
Facts about Segment polarity protein dishevelled homolog DVL-2.
Segment polarity protein dishevelled homolog DVL-2 (DVL2)
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C- terminus of frizzled family members and transducing the Wnt signal to down-stream effectors.
Promotes internalization and degradation of frizzled proteins upon Wnt signaling. .
Gene Information
| Human | |
|---|---|
| Gene Name: | DVL2 |
| Uniprot: | O14641 |
| Entrez: | 1856 |
Family
| Belongs to: |
|---|
| DSH family |
Alternative Names
dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2 (Drosophila); Dishevelled2; Dishevelled-2; DSH homolog 2; DVL2; segment polarity protein dishevelled homolog DVL-2
Molecular Weight
Mass (kDA):
78.948 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7225341..7234544, complement) |
Subcellular Localizations
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Nucleus. Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Colorectal Cancer
- Cell Invasion
- Crest Syndrome
- Malignant Neoplasm Of Stomach
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Ulcer
- Congenital Abnormality
Interacting Proteins
- APC
- AXIN1
- DACT1
- DIXDC1
- LRRK2
- Pard6a
- RIPK4
- Smurf2
- TIFA
- TP53
Pathways
- Localization
- Cell Migration
- Cell Proliferation
- Convergent Extension
- Neural Tube Closure
- Tube Closure
- Cell Cycle
- Endocytosis
- Cell Growth
- Cell Adhesion
- Segmentation
- Rna Interference
- Cell Motility
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DVL2
bosterbio.com/bosterbio-gene-info-cards/DVL2
References
PMID: 9192851 by Semenov M.V., et al. Human dishevelled genes constitute a DHR-containing multigene family.
PMID: 11742073 by Chen W., et al. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.